Ben Abda Imène, Ben-Abdallah Rym, Hammami Houda, Ben Abid Meriem, Mdimagh-Kchir Hela, Bahri Karim, Siala Emna, Aoun Karim, Bouratbine Aida
Department of Parasitology, Pasteur Institute of Tunis, Tunisia.
Research Laboratory Medical Parasitology, Biotechnology and Biomolecule LR11IPT-06, University Tunis El-Manar, Pasteur Institute of Tunis, Tunisia.
Pan Afr Med J. 2019 Sep 3;34:8. doi: 10.11604/pamj.2019.34.8.18946. eCollection 2019.
We report here a case of simultaneous cutaneous and visceral manifestations due to diagnosed in an immunocompetent adult. We describe a 74-year-old woman from Tunis, Tunisia, who presented a biologically confirmed visceral leishmaniasis infection concomitant with arm ulceration which appeared 2 years before. DNA was detected by ITS PCR in both buffy coat and dermal scrapping of the arm lesion. Sequencing revealed that the 2 isolated strains corresponded to and were 100% identical. The symptoms of visceral leishmaniasis responded to amphotericin B with rapid healing. However, the skin lesion did not improve although PCR on dermal sample became negative. This location is probably secondarily to lymphatic or blood dissemination during the systemic visceral leishmaniasis infection. It would be favored by the inflammatory environment induced by the basal cell carcinoma subsequently diagnosed.
我们在此报告一例在免疫功能正常的成年人中诊断出的同时伴有皮肤和内脏表现的病例。我们描述了一位来自突尼斯突尼斯市的74岁女性，她经生物学确诊患有内脏利什曼病感染，同时伴有两年前出现的手臂溃疡。在手臂病变的血沉棕黄层和皮肤刮片中通过ITS PCR检测到了DNA。测序显示，分离出的2株菌株对应于[具体内容缺失]且100%相同。内脏利什曼病的症状对两性霉素B有反应，迅速愈合。然而，尽管皮肤样本的PCR检测结果变为阴性，但皮肤病变并未改善。该部位可能继发于系统性内脏利什曼病感染期间的淋巴或血液传播。随后诊断出的基底细胞癌所诱导的炎症环境可能对此起到了促进作用。
