Hadjkacem Faten, Kalthoum Mahdi, Ghorbel Dorra, Ammar Mouna, Elleuch Mouna, Charfi Nadia, Mnif Mouna, Abid Mohamed
Service d'Endocrinologie et Diabétologie de CHU Hédi Chaker, route El-Ain, 3029 Sfax, Tunisie.
Pan Afr Med J. 2019 Sep 16;34:32. doi: 10.11604/pamj.2019.34.32.14865. eCollection 2019.
Pancreatic insulinoma is a rare, often benign, neuroendocrine tumor which may give rise to life-threatening consequences due to hypoglycemia-related accidents. Adrenal deficiency can also cause hypoglycemia. We report the case of a 68-year old patient hospitalized for recurrent hypoglycaemia. Tests were performed that showed endogenous hyperinsulinism, adrenocorticotropin deficiency and hypergonadotropic hypogonadism. The patient received hydrocortisone without improvement. Five years later topography showed insulinoma. This study highlights the clinical, biological, radiological and therapeutic features of insulinoma as well as laboratory test results and shows that insulinoma can cause adrenocorticotropic deficiency and peripheral hypogonadism.
胰腺胰岛素瘤是一种罕见的、通常为良性的神经内分泌肿瘤，可因低血糖相关事件导致危及生命的后果。肾上腺功能不全也可引起低血糖。我们报告一例68岁因反复低血糖住院的患者。所做检查显示内源性高胰岛素血症、促肾上腺皮质激素缺乏和高促性腺激素性性腺功能减退。患者接受氢化可的松治疗但无改善。五年后影像学检查显示胰岛素瘤。本研究突出了胰岛素瘤的临床、生物学、放射学和治疗特点以及实验室检查结果，并表明胰岛素瘤可导致促肾上腺皮质激素缺乏和外周性腺功能减退。
