Mittendorf Elizabeth A, Liu Yao-Chang, McHenry Christopher R
Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20762, USA.
J Clin Endocrinol Metab. 2005 Jan;90(1):575-80. doi: 10.1210/jc.2004-0825. Epub 2004 Nov 2.
An insulinoma is a rare pancreatic endocrine tumor that is typically sporadic, solitary, and less than 2 cm in diameter. Fewer than 5% of insulinomas are larger than 3 cm. Ninety percent or more of all insulinomas are benign. Larger tumors are more likely to be malignant. We report a case of a giant pedunculated insulinoma, measuring 9 cm in diameter and weighing 100 g, with amyloid deposits accounting for 70% of the tumor volume. At the time of operation, no local invasion or metastatic disease was identified. On pathological evaluation, the tumor was classified as an insulinoma of uncertain biological behavior. In addition to describing the clinical presentation and operative findings, criteria for determining malignancy are outlined, a detailed pathological description is presented, and the 2000 World Health Organization Classification for Pancreatic Endocrine Neoplasms is reviewed.
胰岛素瘤是一种罕见的胰腺内分泌肿瘤，通常为散发性、孤立性，直径小于2厘米。不到5%的胰岛素瘤直径大于3厘米。所有胰岛素瘤中90%或更多为良性。较大的肿瘤更有可能是恶性的。我们报告一例巨大带蒂胰岛素瘤，直径9厘米，重100克，淀粉样沉积物占肿瘤体积的70%。手术时，未发现局部侵犯或转移性疾病。经病理评估，该肿瘤被分类为生物学行为不确定的胰岛素瘤。除了描述临床表现和手术发现外，还概述了确定恶性肿瘤的标准，给出了详细的病理描述，并回顾了2000年世界卫生组织胰腺内分泌肿瘤分类。
