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多功能矿物水凝胶:在人工智能皮肤和药物递送中的潜力。

Multifunctional Mineral Hydrogels: Potential in Artificially Intelligent Skins and Drug Delivery.

作者信息

Yan Jufen, Zhu Jianhua, Cui Mingfang, Zhang Jing, Ma Fang, Su Yiping, Han Xinya

机构信息

Department of Chemistry and Chemical Engineering and Key Laboratory of Metallurgical Emission Reduction & Resources Recycling (Ministry of Education), Anhui University of Technology, Maanshan 243002, China.

School of Environmental Science and Engineering, Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China.

出版信息

ACS Omega. 2019 Nov 6;4(21):19145-19152. doi: 10.1021/acsomega.9b02435. eCollection 2019 Nov 19.

Abstract

Hydrogels have received considerable attention due to their potential applications in the fields of drug delivery, tissue engineering, and stimuli-responsive devices. Nonetheless, it is still a great difficulty in designing hydrogels with multifunctional characteristics including excellent antibacterial activity and appropriate mechanical and remarkable sensing properties. In the present study, a novel type of organic-inorganic adhesive is demonstrated, which comprises inorganic matter of amorphous calcium phosphate particles and organic substances of poly(acrylic acid) and chitosan. The hydrogel possesses excellent biocompatible and antibacterial activity, unique viscoelastic properties, high quantity of drug load, and remarkably sensitive pressure sensing, which have potential use as antibacterial biomaterials, artificially intelligent skins, and drug delivery carriers.

摘要

水凝胶因其在药物递送、组织工程和刺激响应装置等领域的潜在应用而受到了广泛关注。尽管如此,设计具有多功能特性(包括优异的抗菌活性、适当的机械性能和显著的传感性能)的水凝胶仍然是一个巨大的难题。在本研究中,展示了一种新型的有机-无机粘合剂,它由无定形磷酸钙颗粒的无机物和聚丙烯酸与壳聚糖的有机物组成。该水凝胶具有优异的生物相容性和抗菌活性、独特的粘弹性、高载药量以及显著灵敏的压力传感性能,具有作为抗菌生物材料、人工智能皮肤和药物递送载体的潜在用途。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4900/6868877/d39474cd07c2/ao9b02435_0003.jpg

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