Department of Polymer Science and Engineering, Key Laboratory of Systems Bioengineering (Ministry of Education), School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China.
J Mater Chem B. 2019 Dec 21;7(47):7490-7493. doi: 10.1039/c9tb02174d. Epub 2019 Nov 25.
Bortezomib, dietary tannic acid and an FDA-approved excipient poloxamer were used as building blocks without any chemical syntheses and modifications to construct a dynamic self-delivery nanodrug with high drug loading, outstanding stability, tunable size and pH-controlled release. This strategy with high druggability, reproducibility and productivity might be desirable and useful for pharmaceutical formulations of bortezomib.
硼替佐米、膳食单宁酸和一种获得 FDA 批准的辅料泊洛沙姆被用作构建模块，无需进行任何化学合成和修饰，即可构建具有高载药量、出色稳定性、可调节尺寸和 pH 控制释放的动态自递药纳米药物。这种具有高成药性、可重复性和生产力的策略可能是理想和有用的硼替佐米药物制剂。
