Natural Sciences and Science Education, National Institute of Education , Nanyang Technological University , 1 Nanyang Walk , Singapore 637616 , Singapore.
School of Biological Sciences , Nanyang Technological University , 60 Nanyang Drive , Singapore 637551 , Singapore.
J Nat Prod. 2019 Dec 27;82(12):3482-3488. doi: 10.1021/acs.jnatprod.9b00675. Epub 2019 Nov 25.
A new cyclic decapeptide, trikoramide A (), has been isolated from samples of the marine cyanobacterium , collected from Bintan Island, Indonesia. Trikoramide A () is a C-prenylated cyclotryptophan-containing cyanobactin. Its planar structure was deduced by 1D and 2D NMR spectroscopy as well as HR-MS/MS data. In addition, its absolute configuration was determined by Marfey's method and 2D NOESY NMR spectroscopic analysis. Compound possessed cytotoxicity against the MOLT-4 and AML2 cancer cell lines with IC values of 4.8 and 8.2 μM, respectively.
一种新的环状十肽，三考酰胺 A ()，已从印度尼西亚民丹岛采集的海洋蓝细菌样本中分离出来。三考酰胺 A () 是一种 C-异戊烯基化的环色氨酸含蓝细菌素。其平面结构通过 1D 和 2D NMR 光谱以及高分辨质谱/质谱联用 (HR-MS/MS) 数据推导得出。此外，其绝对构型通过 Marfey 法和二维 NOESY NMR 光谱分析确定。化合物 对 MOLT-4 和 AML2 癌细胞系具有细胞毒性，IC 值分别为 4.8 和 8.2 μM。
