Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China.
Mar Drugs. 2021 Nov 24;19(12):658. doi: 10.3390/md19120658.
Indole alkaloids are heterocyclic natural products with extensive pharmacological activities. As an important source of lead compounds, many clinical drugs have been derived from natural indole compounds. Marine indole alkaloids, from unique marine environments with high pressure, high salt and low temperature, exhibit structural diversity with various bioactivities, which attracts the attention of drug researchers. This article is a continuation of the previous two comprehensive reviews and covers the literature on marine indole alkaloids published from 2015 to 2021, with 472 new or structure-revised compounds categorized by sources into marine microorganisms, invertebrates, and plant-derived. The structures and bioactivities demonstrated in this article will benefit the synthesis and pharmacological activity study for marine indole alkaloids on their way to clinical drugs.
吲哚生物碱是具有广泛药理活性的杂环天然产物。作为重要的先导化合物来源，许多临床药物都是从天然吲哚化合物衍生而来的。海洋吲哚生物碱来源于高压、高盐和低温等独特的海洋环境，具有结构多样性和各种生物活性，引起了药物研究人员的关注。本文是前两篇综述的延续，涵盖了 2015 年至 2021 年发表的海洋吲哚生物碱文献，根据来源将 472 个新的或结构修订的化合物分为海洋微生物、无脊椎动物和植物来源。本文中展示的结构和生物活性将有助于海洋吲哚生物碱的合成和药理活性研究，使其走向临床药物。
