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离子液体在治疗和药物传递应用中的应用。

Ionic Liquids for Therapeutic and Drug Delivery Applications.

机构信息

Chitkara College of Pharmacy, Chitkara University, Punjab, India.

出版信息

Curr Drug Res Rev. 2020;12(1):26-41. doi: 10.2174/2589977511666191125103338.

Abstract

BACKGROUND

Ionic liquids (ILs) are ionic compounds with highly tunable and remarkable properties which make them an important candidate in multiple domains such as extraction, synthesis, analytics, catalysis, biotechnology, therapeutics as well as pharmaceutical sciences.

OBJECTIVE

This review systematically highlights the classification, properties and toxicity of ionic liquids. It focuses on exploring the biological activity of ionic liquids, which includes antimicrobial and anticancer property along with an emphasis on the concept of Active Pharmaceutical Ingredient- Ionic Liquids (API-ILs) for explaining the emulsifier and solubility enhancement property of ILs. An elaborative discussion on the application of ILs for the development of oral, transdermal and topical drug delivery systems has also been presented with suitable literature support.

CONCLUSION

Ionic liquids possess exceptional potential in the field of medicine, biology and chemistry.

摘要

背景

离子液体(ILs)是具有高度可调且显著性质的离子化合物,这使它们成为多个领域的重要候选物,如萃取、合成、分析、催化、生物技术、治疗学以及药物科学。

目的

本综述系统地强调了离子液体的分类、性质和毒性。它侧重于探索离子液体的生物活性,包括抗菌和抗癌特性,并强调活性药物成分-离子液体(API-ILs)的概念,以解释离子液体的乳化剂和增溶性质。还详细讨论了离子液体在开发口服、透皮和局部药物传递系统方面的应用,并提供了适当的文献支持。

结论

离子液体在医学、生物学和化学领域具有特殊的潜力。

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