LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, 4169-007, Porto, Portugal.
CIQ-UP, Centro de Investigação em Química da Universidade do Porto, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Rua do Campo Alegre 687, 4169-007, Porto, Portugal.
ChemMedChem. 2021 Sep 6;16(17):2604-2611. doi: 10.1002/cmdc.202100215. Epub 2021 Jun 9.
The relevance of ionic liquids (ILs) is now well established in many fields, as their unique properties make them appealing as 1) greener alternatives to organic solvents (first-generation ILs), 2) tunable task-specific materials (second-generation ILs), and 3) multifunctional players in life and pharmaceutical sciences (third-generation ILs). This third wave of ILs encompasses a wide range of compounds, from bioactive molecules with single or even dual therapeutic action, to potential ingredient molecules for drug formulation and transport systems. In this context, the focus of this review is the emergent role of surface-active ionic liquids (SAILs) in drug development and delivery.
离子液体（ILs）在许多领域的相关性现在已经得到很好的确立，因为它们独特的性质使它们成为有吸引力的 1）更环保的有机溶剂替代品（第一代 ILs），2）可调任务特定材料（第二代 ILs），以及 3）生命和制药科学中的多功能参与者（第三代 ILs）。第三代 ILs 涵盖了广泛的化合物，从具有单一甚至双重治疗作用的生物活性分子，到药物制剂和输送系统的潜在成分分子。在这种情况下，本综述的重点是表面活性离子液体（SAILs）在药物开发和传递中的新兴作用。
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