Orzeł H, Tchórzewski H
Arch Immunol Ther Exp (Warsz). 1979;27(5):687-91.
An experimental study in rabbits and clinical study in patients with uveitis was carried out. Experimental uveitis was induced in rabbits sensitized with albumin and antigen was injected intravenously or into the vitrous body of their eyes. Blastic transformation of lymphocytes stimulated with PHA, albumin and extracts of the uvea and cytotoxicity of the serum against normal white blood cells in presence of antigen were determined. In recurrent uveitis blastic transformation induced with uvea antigens, hemagglutinin titers against these antigens and serum cytotoxicity increased. The results indicate a significant role of autoaggression in the pathogenesis of some recurrent eye uveitis cases.
对兔子进行了一项实验研究，并对葡萄膜炎患者进行了临床研究。在用白蛋白致敏的兔子中诱发实验性葡萄膜炎，然后将抗原静脉注射或注入其眼玻璃体内。测定了用PHA、白蛋白和葡萄膜提取物刺激的淋巴细胞的母细胞转化以及在有抗原存在时血清对正常白细胞的细胞毒性。在复发性葡萄膜炎中，葡萄膜抗原诱导的母细胞转化、针对这些抗原的血凝素滴度和血清细胞毒性增加。结果表明自身攻击在一些复发性眼部葡萄膜炎病例的发病机制中起重要作用。
