Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
The George Institute for Global Health, University of New South Wales, Sydney, Australia.
J Hypertens. 2020 Mar;38(3):387-394. doi: 10.1097/HJH.0000000000002298.
Although the causality of the obesity--hypertension association is established, the potential for prevention is not. We hypothesized that weight gain between early adulthood and mid-life is associated with higher mid-life blood pressure.
We investigated the hypothesis using a large contemporaneous population-based mid-life cohort of men and women aged 50-64 years. Recalled body weight at age 20 years was self-reported, and mid-life body weight and office blood pressures were measured in accordance with a detailed protocol.
On average, men had gained 14.9 (95% CI 14.6-15.2) kg of weight, and women 14.6 (95% CI 14.4-14.9) kg, between age 20 years and the mid-life examination, corresponding to 0.40 (95% CI 0.39-0.41) kg/year for men and women. Both weight at age 20 years and weight at the mid-life examination were associated with mid-life blood pressures. On average, a 10 kg weight increase between age 20 years and mid-life was associated with 2.2 (95% CI 0.9-3.5) mmHg higher systolic and 1.7 (95% CI 0.9-2.5) mmHg higher diastolic mid-life blood pressure in men, and 3.2 (2.5-4.0) mmHg higher systolic and 2.4 (1.9-2.9) mmHg higher diastolic mid-life blood pressure in women. Mid-life weight was more closely associated than weight at age 20 years with mid-life blood pressure. For a given mid-life weight, blood pressure was higher in persons with higher weight gain from age 20 years.
In sum, weight gain between early adulthood and mid-life was associated with higher mid-life blood pressure. The magnitude of the association indicates a potentially great public health impact of strategies to prevent weight gain throughout adulthood.
尽管肥胖与高血压之间的因果关系已经确立，但潜在的预防措施尚未确定。我们假设，成年早期到中年期间的体重增加与中年时的血压升高有关。
我们使用一个大型的同期中年人群队列研究，该队列研究包括年龄在 50-64 岁的男性和女性，来验证这一假设。20 岁时的体重回忆是通过自我报告获得的，而中年体重和办公室血压则按照详细的方案进行测量。
平均而言，男性体重增加了 14.9（95%置信区间 14.6-15.2）kg，女性增加了 14.6（95%置信区间 14.4-14.9）kg，这相当于男性和女性每年体重增加 0.40（95%置信区间 0.39-0.41）kg。20 岁时的体重和中年时的体重均与中年时的血压有关。平均而言，20 岁到中年期间体重增加 10kg 与男性的收缩压升高 2.2（95%置信区间 0.9-3.5）mmHg 和舒张压升高 1.7（95%置信区间 0.9-2.5）mmHg 以及女性的收缩压升高 3.2（2.5-4.0）mmHg 和舒张压升高 2.4（1.9-2.9）mmHg 有关。与 20 岁时的体重相比，中年时的体重与中年时的血压更为密切相关。对于给定的中年体重，体重增加较多的人血压更高。
总之，成年早期到中年期间的体重增加与中年时的血压升高有关。这种关联的幅度表明，通过在整个成年期预防体重增加来预防肥胖的策略可能具有巨大的公共卫生影响。
