Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran.
Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.
BMC Complement Med Ther. 2024 Nov 25;24(1):406. doi: 10.1186/s12906-024-04701-0.
Mentha consumption may associated with blood pressure improvement in humans, but the recent evidence from randomized controlled trials (RCTs) showed inconsistent results. The present study provides a systematic review and meta-analysis of RCTs to investigate the effect of Mentha on blood pressure.
To cover all relevant literature, a complete search was conducted across PubMed, ISI Web of Science, and SCOPUS databases before March 2024 using PRISMA guidelines. In addition, Google Scholar, SID databases, the reference lists of the related reviews, and meta-analyses were searched for this purpose. Also, a "snowball search" was applied to include other relevant trials that may have been missed. A random-effects model was used for quantitative data synthesis, with weight mean difference (WMD) and 95% confidence intervals (CI). Standard methodologies were utilized to assess kappa statistics between the authors, GRADE evidence profiles, heterogeneity, meta-regression, sensitivity analysis, and publication bias.
Out of 476 publications identified, seven RCTs were eligible and included in this systematic review and meta-analysis. There was perfect agreement in study selection between the reviewers (К statistic, 0.86; p < 0.001). Meta-analysis showed a 1.227 mmHg reduction in systolic blood pressure (SBP) (95% CI: -6.61,4.16, p = 0.655), 2.997 mmHg reduction in long-term SBP (95% CI: -8.00,2.00, p = 0.241), 1.830 mmHg reduction in diastolic blood pressure (DBP) (95% CI: -5.06,1.40, p = 0.268), and 2.857 mmHg reduction in long-term DBP (95% CI: -6.01, 0.30, p = 0.076) after Mentha consumption in intervention group compared to control. In sub-group analysis, a statistically and clinically significant reduction in SBP and DBP was observed in the participants with ages above 30 years and in the participants with SBP > 130 mmHg or DBP > 80 mmHg.
Our findings showed that Mentha consumption might not have a statistically significant effect on lowering SBP, DBP, long-term SBP, and long-term DBP. However, it can lead to a clinically significant reduction in both long-term SBP and long-term DBP. Besides, Mentha may have potential benefits for patients with pre-hypertension and hypertension. Nevertheless, further well-designed RCTs are needed to confirm our results. PROSPERO Registration No: CRD42023459490.
薄荷的摄入可能与人类血压的改善有关，但最近来自随机对照试验 (RCT) 的证据显示结果不一致。本研究通过系统评价和荟萃分析 RCT 来调查薄荷对血压的影响。
为了涵盖所有相关文献，根据 PRISMA 指南，在 2024 年 3 月之前在 PubMed、ISI Web of Science 和 SCOPUS 数据库中进行了全面检索。此外，还为此目的在 Google Scholar、SID 数据库、相关综述和荟萃分析的参考文献列表中进行了搜索。此外，还应用了“滚雪球搜索”来包括可能遗漏的其他相关试验。使用随机效应模型进行定量数据合并，使用加权均数差 (WMD) 和 95%置信区间 (CI)。利用kappa 统计量、GRADE 证据概况、异质性、meta 回归、敏感性分析和发表偏倚来评估作者之间的标准方法。
在 476 篇已识别的出版物中，有 7 项 RCT 符合纳入标准并被纳入本系统评价和荟萃分析。两位审稿人在研究选择上完全一致（κ统计量，0.86；p<0.001）。荟萃分析显示收缩压 (SBP) 降低 1.227mmHg（95%CI：-6.61，4.16，p=0.655），长期 SBP 降低 2.997mmHg（95%CI：-8.00，2.00，p=0.241），舒张压 (DBP) 降低 1.830mmHg（95%CI：-5.06，1.40，p=0.268），长期 DBP 降低 2.857mmHg（95%CI：-6.01，0.30，p=0.076）在干预组中薄荷摄入后与对照组相比。在亚组分析中，年龄在 30 岁以上的参与者以及 SBP>130mmHg 或 DBP>80mmHg 的参与者中，SBP 和 DBP 均有统计学和临床意义上的降低。
我们的研究结果表明，薄荷的摄入可能不会对降低 SBP、DBP、长期 SBP 和长期 DBP 有统计学意义。然而，它可以导致长期 SBP 和长期 DBP 的临床显著降低。此外，薄荷可能对高血压前期和高血压患者有潜在益处。然而，需要进一步设计良好的 RCT 来证实我们的结果。PROSPERO 注册号：CRD42023459490。
