消防员在扑灭野火时的急性炎症反应。

Firefighter's Acute Inflammatory Response to Wildfire Suppression.

机构信息

Institute for Physical Activity and Nutrition (Dr Main, Dr Wolkow, Dr Della Gatta, Dr Raines, Dr Snow, Dr Aisbett); School of Exercise and Nutrition Sciences, Deakin University, Burwood (Dr Tait); School of Psychological Sciences, Monash Institute of Cognitive and Clinical Neuroscience, Monash University, Clayton, VIC (Dr Wolkow), Australia.

出版信息

J Occup Environ Med. 2020 Feb;62(2):145-148. doi: 10.1097/JOM.0000000000001775.

DOI:10.1097/JOM.0000000000001775

PMID:31764604

Abstract

OBJECTIVES

The purpose of this study was to determine the inflammatory response to a 12-hour wildfire suppression shift, in firefighters attending the "Black Saturday" natural disaster.

METHODS

Thirty-eight male volunteer firefighters provided venous blood samples before and after a 12-hour firefighting shift. Pre- to post-shift changes in pro-inflammatory (Interleukin [IL]-1β, IL-2, IL-6, IL-8, IL-12P70, granulocyte macrophage-colony stimulating factor [GM-CSF], tumor necrosis factor-alpha [TNF-α], interferon-gamma [IFNγ]), and anti-inflammatory (IL-4, IL-5, IL-7, IL-10, IL-13) cytokines were measured with paired sample t tests, or Wilcoxon t tests for non-parametric data.

RESULTS

Interleukin (IL)-6 (P = 0.003) and IL-8 (P = 0.017) were significantly increased following 12-hours of wildfire suppression. There was also a significant decrease in IL-10 (P = 0.021).

CONCLUSIONS

The observed acute inflammatory response may have resulted from multiple stressors including physical exertion, thermal strain, or smoke inhalation experienced during the shift, and may be a necessary response for the body to adapt to stressor exposure.

摘要

目的

本研究旨在确定参与“黑色星期六”自然灾害的消防员在进行 12 小时灭火任务后的炎症反应。

方法

38 名男性志愿消防员在 12 小时灭火任务前后提供静脉血样。采用配对样本 t 检验或非参数数据的 Wilcoxon t 检验，比较炎症前（白细胞介素[IL]-1β、IL-2、IL-6、IL-8、IL-12P70、粒细胞巨噬细胞集落刺激因子[GM-CSF]、肿瘤坏死因子-α[TNF-α]、干扰素-γ[IFNγ]）和抗炎（IL-4、IL-5、IL-7、IL-10、IL-13）细胞因子在灭火任务前后的变化。