Paris-Saclay University, Paris-South University, Université Versailles Saint-Quentin-en-Yvelines (UVSQ), Center for Research in Epidemiology and Population Health, INSERM, Villejuif, France.
University of Bordeaux, Institut National de la Santé et de la Recherche Médicale (INSERM), Bordeaux Population Health Research Center, UMR 1219, CHU Bordeaux, Bordeaux, France.
J Am Geriatr Soc. 2020 Mar;68(3):585-594. doi: 10.1111/jgs.16257. Epub 2019 Nov 25.
BACKGROUND/OBJECTIVES: The associations of reproductive history and motor function are controversial.
Prospective cohort study with 10 years of follow-up.
Three French cities between 1999 and 2011.
A total of 3043 community-dwelling women from the Three-City Dijon study population.
We examined the cross-sectional and longitudinal association of age at menopause, artificial menopause, and parity with walking speed (WS) using linear regression and linear mixed models, respectively. Cox proportional models were used to examine the association of characteristics of reproductive life with disability.
Mean baseline WS was 143.8 cm/s. Artificial menopause was associated with slower WS at baseline (β = -3.29; 95% confidence interval [CI] = -5.83 to -0.74; P = .01). Reproductive life characteristics had no effect on change in WS. Increasing age at menopause was associated with reduced disability risk (hazard ratio [HR] for 5-year increase = 0.92; 95% CI = 0.87-0.99; P = .02), while parity increased disability risk (HR for ≥3 vs 0 children = 1.53; 95% CI = 1.22-1.93; P < .01).
These findings show that early age at menopause and higher parity have a deleterious effect on motor function that persists in older people. J Am Geriatr Soc 68:585-594, 2020.
背景/目的：生殖史与运动功能之间的关联尚存在争议。
前瞻性队列研究，随访 10 年。
1999 年至 2011 年间法国的三个城市。
来自迪戎三城研究人群的 3043 名社区居住的女性。
我们使用线性回归和线性混合模型分别检查绝经年龄、人工绝经和生育次数与步行速度（WS）的横断面和纵向关联。使用 Cox 比例风险模型来检验生殖生活特征与残疾的关联。
平均基线 WS 为 143.8 cm/s。人工绝经与基线时 WS 较慢相关（β=-3.29；95%置信区间[CI]：-5.83 至 -0.74；P=.01）。生殖生活特征对 WS 的变化没有影响。绝经年龄增加与残疾风险降低相关（每增加 5 年的风险比[HR]为 0.92；95%CI：0.87-0.99；P=.02），而生育次数增加与残疾风险增加相关（≥3 次与 0 次生育的 HR 为 1.53；95%CI：1.22-1.93；P<.01）。
这些发现表明，早绝经和多育对运动功能有不良影响，这种影响在老年人中持续存在。美国老年学会杂志 68：585-594，2020 年。
