Laboratory of Cancer Biology and Epigenetics, Department of Cell Biology and Genetics, Shantou University Medical College, Shantou, Guangdong 515041, China.
Molecules. 2019 Nov 21;24(23):4246. doi: 10.3390/molecules24234246.
Cancer is one of the foremost causes of death globally and also the major stumbling block of increasing life expectancy. Although the primary treatment of surgical resection, chemotherapy, and radiotherapy have greatly reduced the mortality of cancer, the survival rate is still low because of the metastasis of tumor, a range of adverse drug reactions, and drug resistance. For all this, it is relevant to mention that a growing amount of research has shown the anticarcinogenic effect of phytochemicals which can modulate the molecular pathways and cellular events include apoptosis, cell proliferation, migration, and invasion. However, their pharmacological potential is hindered by their low water solubility, low stability, poor absorption, and rapid metabolism. In this scenario, the development of nanotechnology has created novel formulations to maximize the potential use of phytochemicals in anticancer treatment. Nanocarriers can enhance the solubility and stability of phytochemicals, prolong their half-life in blood and even achieve site-targeting delivery. This review summarizes the advances in utilizing nanoparticles in cancer therapy. In particular, we introduce several applications of nanoparticles combined with apigenin, resveratrol, curcumin, epigallocatechin-3-gallate, 6-gingerol, and quercetin in cancer treatment.
癌症是全球首要致死原因之一，也是延长预期寿命的主要障碍。尽管手术切除、化疗和放疗等主要治疗方法大大降低了癌症的死亡率，但由于肿瘤转移、一系列不良反应和耐药性的存在，其存活率仍然较低。为此，值得一提的是，越来越多的研究表明，植物化学物质具有抗癌作用，可以调节包括细胞凋亡、细胞增殖、迁移和侵袭在内的分子途径和细胞事件。然而，由于其水溶性低、稳定性差、吸收不良和代谢迅速，它们的药理潜力受到限制。在这种情况下，纳米技术的发展创造了新的制剂，以最大限度地提高植物化学物质在抗癌治疗中的潜在用途。纳米载体可以提高植物化学物质的溶解度和稳定性，延长其在血液中的半衰期，甚至实现靶向递药。本综述总结了利用纳米颗粒在癌症治疗中的进展。特别是，我们介绍了几种纳米颗粒与芹菜素、白藜芦醇、姜黄素、表没食子儿茶素没食子酸酯、6-姜酚和槲皮素在癌症治疗中的应用。
