• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

5''-羟基异紫堇醇酯的三十烷酸酯：通过Bcl-2、BAX和半胱天冬酶-3介导的信号通路在宫颈癌中的肿瘤抑制作用

Triacontanoic ester of 5''-hydroxyjustisolin: Tumour suppressive role in cervical cancer via Bcl-2, BAX and caspase-3 mediated signalling.

作者信息

Joseph Litty, Srinivasan K K

机构信息

Department of Pharmaceutical Sciences, Centre for Professional and Advanced studies, Cheruvandoor Campus, Ettumanoor PO, Kottayam, 686 631, Kerala, India.

Department of Chemistry, Shri Madhwa Vadiraja Institute of Technology and Management, Bantakal, Udupi, 574 115, Karnataka, India.

出版信息

Toxicol Rep. 2019 Oct 31;6:1198-1205. doi: 10.1016/j.toxrep.2019.10.015. eCollection 2019.

DOI:10.1016/j.toxrep.2019.10.015
PMID:31768331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6872787/
Abstract

Triacontanoic ester of 5"-hydroxyjustisolin, a lignan from D. Don, possesses antitumor activity. However, the molecular mechanism underlying this is not yet clearly understood. The present study showed significant inhibition in cell viability on HeLa cell line and induced minor toxicity in normal cells. This compound induced mitotic arrest at G0/G1 phase followed by apoptosis in human cervical cancer cells and was accompanied by the upregulation of BAX, caspase-3 and downregulation of Bcl-2. Taken together, these data reveal that the title compound acts through multiple cellular/molecular pathways, which strongly suggest the role of pro and antiapoptotic Bcl-2 family proteins. Triacontanoic ester of 5''-hydroxyjustisolin may be a potential agent for the cervical cancer treatment.

摘要

5”-羟基异落叶松脂素的三十烷酸酯是一种从D. Don中提取的木脂素，具有抗肿瘤活性。然而，其潜在的分子机制尚未完全明确。本研究表明，该化合物对HeLa细胞系的细胞活力有显著抑制作用，且对正常细胞产生轻微毒性。该化合物可诱导人宫颈癌细胞在G0/G1期发生有丝分裂停滞，随后引发凋亡，同时伴随着BAX、caspase-3的上调以及Bcl-2的下调。综上所述，这些数据表明该标题化合物通过多种细胞/分子途径发挥作用，这强烈提示了促凋亡和抗凋亡Bcl-2家族蛋白的作用。5”-羟基异落叶松脂素的三十烷酸酯可能是一种治疗宫颈癌的潜在药物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/4f72b9f241dd/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/0d7b328e6f4e/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/f02135b05045/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/f313be0917b7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/62c67827d5d9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/074bc0e2476c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/a583a523cf01/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/4064e105c4a2/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/86633d63e11b/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/4f72b9f241dd/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/0d7b328e6f4e/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/f02135b05045/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/f313be0917b7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/62c67827d5d9/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/074bc0e2476c/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/a583a523cf01/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/4064e105c4a2/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/86633d63e11b/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/583e/6872787/4f72b9f241dd/gr8.jpg

相似文献

1
Triacontanoic ester of 5''-hydroxyjustisolin: Tumour suppressive role in cervical cancer via Bcl-2, BAX and caspase-3 mediated signalling.5''-羟基异紫堇醇酯的三十烷酸酯：通过Bcl-2、BAX和半胱天冬酶-3介导的信号通路在宫颈癌中的肿瘤抑制作用
Toxicol Rep. 2019 Oct 31;6:1198-1205. doi: 10.1016/j.toxrep.2019.10.015. eCollection 2019.
2
Promising anticancer activities of Justicia simplex D. Don. in cellular and animal models.在细胞和动物模型中，莕菜具有有前景的抗癌活性。
J Ethnopharmacol. 2017 Mar 6;199:231-239. doi: 10.1016/j.jep.2017.01.046. Epub 2017 Feb 3.
3
Rutamarin, an Active Constituent from Pers., Induced Apoptotic Cell Death in the HT29 Colon Adenocarcinoma Cell Line.芸香苦素，一种来自Pers.的活性成分，诱导HT29结肠腺癌细胞系发生凋亡性细胞死亡。
Pharmacogn Mag. 2017 Jul;13(Suppl 2):S179-S188. doi: 10.4103/pm.pm_432_16. Epub 2017 Jul 11.
4
Silver Nanoparticles Exhibit the Dose-Dependent Anti-Proliferative Effect against Human Squamous Carcinoma Cells Attenuated in the Presence of Berberine.银纳米颗粒对人鳞状癌细胞具有剂量依赖性抗增殖作用，在小檗碱存在下这种作用减弱。
Molecules. 2016 Mar 17;21(3):365. doi: 10.3390/molecules21030365.
5
β-elemene induces caspase-dependent apoptosis in human glioma cells in vitro through the upregulation of Bax and Fas/ FasL and downregulation of Bcl-2.β-榄香烯通过上调Bax和Fas/FasL以及下调Bcl-2，在体外诱导人胶质瘤细胞发生半胱天冬酶依赖性凋亡。
Asian Pac J Cancer Prev. 2014;15(23):10407-12. doi: 10.7314/apjcp.2014.15.23.10407.
6
Mitofusin-2 Triggers Cervical Carcinoma Cell Hela Apoptosis via Mitochondrial Pathway in Mouse Model.在小鼠模型中，线粒体融合蛋白2通过线粒体途径触发宫颈癌细胞Hela凋亡。
Cell Physiol Biochem. 2018;46(1):69-81. doi: 10.1159/000488410. Epub 2018 Mar 20.
7
Antitumor activity of the bark phytochemical ailanthone against breast cancer MCF-7 cells.臭椿酮对乳腺癌MCF-7细胞的抗肿瘤活性。
Oncol Lett. 2018 Apr;15(4):6022-6028. doi: 10.3892/ol.2018.8039. Epub 2018 Feb 13.
8
Cytotoxicity Studies of the Extracts, Fractions, and Isolated Compound of on Cervical Cancer (HeLa), Breast Cancer (MCF-7) and Skeletal Muscle Cancer (RD) Cells.提取物、馏分及分离化合物对子宫颈癌（HeLa）、乳腺癌（MCF - 7）和骨骼肌癌（RD）细胞的细胞毒性研究。
Pharmacognosy Res. 2017 Jan-Mar;9(1):46-50. doi: 10.4103/0974-8490.199776.
9
Antitumor effect and apoptosis induction of Alocasia cucullata (Lour.) G. Don in human gastric cancer cells in vitro and in vivo.海芋对人胃癌细胞的体内外抗肿瘤作用及诱导凋亡作用
BMC Complement Altern Med. 2015 Feb 26;15:33. doi: 10.1186/s12906-015-0554-2.
10
Role of caspases, Bax and Bcl-2 in chrysin-induced apoptosis in the A549 human lung adenocarcinoma epithelial cells.半胱天冬酶、Bax和Bcl-2在白杨素诱导人肺腺癌上皮细胞A549凋亡中的作用。
Anticancer Agents Med Chem. 2014;14(6):901-9. doi: 10.2174/1871520614666140209144042.

引用本文的文献

1
Tubeimoside-1 Enhances TRAIL-Induced Apoptotic Cell Death through STAMBPL1-Mediated c-FLIP Downregulation.管花苷-1 通过 STAMBPL1 介导的 c-FLIP 下调增强 TRAIL 诱导的细胞凋亡。
Int J Mol Sci. 2023 Jul 24;24(14):11840. doi: 10.3390/ijms241411840.
2
Resveratrol exhibits neuroprotection against paraquat-induced PC12 cells via heme oxygenase 1 upregulation by decreasing MiR-136-5p expression.白藜芦醇通过降低 miR-136-5p 的表达，通过上调血红素加氧酶 1 发挥对百草枯诱导的 PC12 细胞的神经保护作用。
Bioengineered. 2022 Mar;13(3):7065-7081. doi: 10.1080/21655979.2022.2045764.
3
The Anticancer Effect of a Conjugated Antimicrobial Peptide Against Colorectal Cancer (CRC) Cells.

本文引用的文献

1
NKAP plays an oncogenic function partly through AKT signaling pathway in hepatocellular carcinoma.NKAP 在肝癌中部分通过 AKT 信号通路发挥致癌功能。
Neoplasma. 2019 Jul 12;66(5):792-800. doi: 10.4149/neo_2018_181212N957. Print 2019 Sep.
2
Magnesium sulfate ameliorates carbon monoxide‑induced cerebral injury in male rats.硫酸镁可改善雄性大鼠一氧化碳诱导的脑损伤。
Mol Med Rep. 2019 Feb;19(2):1032-1039. doi: 10.3892/mmr.2018.9771. Epub 2018 Dec 17.
3
Dietary administration of Nexrutine inhibits rat liver tumorigenesis and induces apoptotic cell death in human hepatocellular carcinoma cells.
一种抗菌肽共轭物对结直肠癌细胞（CRC）的抗癌作用。
J Gastrointest Cancer. 2023 Mar;54(1):165-170. doi: 10.1007/s12029-021-00799-4. Epub 2022 Feb 25.
4
Upregulation of DR5 and Downregulation of Survivin by IITZ-01, Lysosomotropic Autophagy Inhibitor, Potentiates TRAIL-Mediated Apoptosis in Renal Cancer Cells via Ubiquitin-Proteasome Pathway.溶酶体促效自噬抑制剂IITZ-01上调DR5并下调Survivin，通过泛素-蛋白酶体途径增强TRAIL介导的肾癌细胞凋亡。
Cancers (Basel). 2020 Aug 21;12(9):2363. doi: 10.3390/cancers12092363.
膳食给予Nexrutine可抑制大鼠肝脏肿瘤发生，并诱导人肝癌细胞发生凋亡性细胞死亡。
Toxicol Rep. 2014 Nov 13;2:1-11. doi: 10.1016/j.toxrep.2014.11.006. eCollection 2015.
4
Promising anticancer activities of Justicia simplex D. Don. in cellular and animal models.在细胞和动物模型中，莕菜具有有前景的抗癌活性。
J Ethnopharmacol. 2017 Mar 6;199:231-239. doi: 10.1016/j.jep.2017.01.046. Epub 2017 Feb 3.
5
Protective effect of erythropoietin on myocardial apoptosis in rats exposed to carbon monoxide.促红细胞生成素对一氧化碳暴露大鼠心肌细胞凋亡的保护作用。
Life Sci. 2016 Mar 1;148:118-24. doi: 10.1016/j.lfs.2016.02.007. Epub 2016 Feb 23.
6
Expression and prognostic role of ubiquitination factor E4B in primary hepatocellular carcinoma.泛素化因子E4B在原发性肝细胞癌中的表达及预后作用
Mol Carcinog. 2016 Jan;55(1):64-76. doi: 10.1002/mc.22259. Epub 2015 Jan 3.
7
Physiological β-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma.生理性β-连环蛋白信号传导控制鼻咽癌的自我更新网络和干细胞样细胞的生成。
BMC Cell Biol. 2013 Sep 27;14:44. doi: 10.1186/1471-2121-14-44.
8
Various methods available for detection of apoptotic cells--a review.检测凋亡细胞的各种可用方法——综述
Indian J Cancer. 2013 Jul-Sep;50(3):274-83. doi: 10.4103/0019-509X.118720.
9
Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.获得性表皮生长因子受体抑制剂耐药与癌细胞表现出干细胞样特性有关。
Cancer Res. 2013 May 15;73(10):3051-61. doi: 10.1158/0008-5472.CAN-12-4136. Epub 2013 Mar 29.
10
Gambogic acid is a tissue-specific proteasome inhibitor in vitro and in vivo.藤黄酸在体外和体内都是一种组织特异性蛋白酶体抑制剂。
Cell Rep. 2013 Jan 31;3(1):211-22. doi: 10.1016/j.celrep.2012.11.023. Epub 2012 Dec 21.