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克罗恩病肠道中的衰老干细胞和短暂扩增细胞。

Senescent Stem and Transient Amplifying Cells in Crohn's Disease Intestine.

机构信息

Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

出版信息

Inflamm Bowel Dis. 2020 Jan 6;26(2):e8-e9. doi: 10.1093/ibd/izz295.

DOI:10.1093/ibd/izz295
PMID:31769481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6943680/
Abstract

We demonstrate presence of senescent (p16, p21) epithelial cells in the stem and transient amplifying cell niches of the intestine in Crohn’s disease. This may explain why Crohn’s lesions recur in the same places.

摘要

我们发现在克罗恩病中，肠道的干细胞和短暂扩增细胞龛中有衰老（p16、p21）的上皮细胞存在。这也许可以解释为什么克罗恩病的病变会在同一部位复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3000/6943680/33416b211c30/izz295f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3000/6943680/33416b211c30/izz295f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3000/6943680/33416b211c30/izz295f0001.jpg

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Inflamm Bowel Dis. 2020 Jan 6;26(2):e8-e9. doi: 10.1093/ibd/izz295.
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本文引用的文献

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Progenitor cell niche senescence reflects pathology of the parotid salivary gland in primary Sjögren's syndrome.祖细胞龛衰老反映了原发性干燥综合征腮腺唾液腺的病理学变化。
Rheumatology (Oxford). 2020 Oct 1;59(10):3003-3013. doi: 10.1093/rheumatology/keaa012.
2
Cellular Senescence: Defining a Path Forward.细胞衰老：定义前进的道路。
Cell. 2019 Oct 31;179(4):813-827. doi: 10.1016/j.cell.2019.10.005.
3
Salivary Gland Stem Cells Age Prematurely in Primary Sjögren's Syndrome.原发性干燥综合征中的唾液腺干细胞过早衰老。
加速生物衰老与炎症性肠病风险：一项针对401,013名参与者的前瞻性研究。
J Nutr Health Aging. 2025 Apr;29(4):100505. doi: 10.1016/j.jnha.2025.100505. Epub 2025 Feb 13.
4
Comment on: "Senolytic Treatment Improve Small Intestine Regeneration in Aging".对《衰老过程中衰老细胞溶解疗法改善小肠再生》的评论
Aging Dis. 2024 Oct 30;16(5):2488. doi: 10.14336/AD.2024.1262.
5
Inflammation and aging-related disease: A transdisciplinary inflammaging framework.炎症与衰老相关疾病：一个跨学科的炎症衰老框架。
Geroscience. 2025 Feb;47(1):515-542. doi: 10.1007/s11357-024-01364-0. Epub 2024 Oct 1.
6
Fisetin modulates the gut microbiota alongside biomarkers of senescence and inflammation in a DSS-induced murine model of colitis.非瑟酮可调节 DSS 诱导的结肠炎小鼠模型中的肠道微生物群以及衰老和炎症的生物标志物。
Geroscience. 2024 Jun;46(3):3085-3103. doi: 10.1007/s11357-024-01060-z. Epub 2024 Jan 8.
7
Cellular microenvironment: a key for tuning mesenchymal stem cell senescence.细胞微环境：调节间充质干细胞衰老的关键
Front Cell Dev Biol. 2023 Dec 4;11:1323678. doi: 10.3389/fcell.2023.1323678. eCollection 2023.
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J Gastrointest Surg. 2023 Jul;27(7):1445-1453. doi: 10.1007/s11605-023-05719-4. Epub 2023 Jun 2.
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