克罗恩病肠道中的衰老干细胞和短暂扩增细胞。
Senescent Stem and Transient Amplifying Cells in Crohn's Disease Intestine.
机构信息
Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Gastroenterology and Hepatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
出版信息
Inflamm Bowel Dis. 2020 Jan 6;26(2):e8-e9. doi: 10.1093/ibd/izz295.
Abstract
We demonstrate presence of senescent (p16, p21) epithelial cells in the stem and transient amplifying cell niches of the intestine in Crohn’s disease. This may explain why Crohn’s lesions recur in the same places.
摘要
我们发现在克罗恩病中，肠道的干细胞和短暂扩增细胞龛中有衰老（p16、p21）的上皮细胞存在。这也许可以解释为什么克罗恩病的病变会在同一部位复发。
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