Sun Wenyang, Lv Jiacheng, Guo Shu, Lv Mengzhu
Department of Plastic Surgery, The First Hospital of China Medical University, Shenyang, Liaoning, China.
Front Cell Dev Biol. 2023 Dec 4;11:1323678. doi: 10.3389/fcell.2023.1323678. eCollection 2023.
Mesenchymal stem cells (MSCs) possess the ability to self-renew and differentiate into multiple cell types, making them highly suitable for use as seed cells in tissue engineering. These can be derived from various sources and have been found to play crucial roles in several physiological processes, such as tissue repair, immune regulation, and intercellular communication. However, the limited capacity for cell proliferation and the secretion of senescence-associated secreted phenotypes (SASPs) pose challenges for the clinical application of MSCs. In this review, we provide a comprehensive summary of the senescence characteristics of MSCs and examine the different features of cellular microenvironments studied thus far. Additionally, we discuss the mechanisms by which cellular microenvironments regulate the senescence process of MSCs, offering insights into preserving their functionality and enhancing their effectiveness.
间充质干细胞（MSCs）具有自我更新和分化为多种细胞类型的能力，使其非常适合用作组织工程中的种子细胞。这些细胞可以来源于多种来源，并已发现在多个生理过程中发挥关键作用，如组织修复、免疫调节和细胞间通讯。然而，细胞增殖能力有限以及衰老相关分泌表型（SASPs）的分泌给MSCs的临床应用带来了挑战。在这篇综述中，我们全面总结了MSCs的衰老特征，并研究了迄今为止所研究的细胞微环境的不同特征。此外，我们讨论了细胞微环境调节MSCs衰老过程的机制，为保持其功能和提高其有效性提供了见解。
