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一项随机研究表明，在中国人群中，透明质酸凝胶治疗后，手背的皮肤质量和美观度得到改善。

A randomized study showing improved skin quality and aesthetic appearance of dorsal hands after hyaluronic acid gel treatment in a Chinese population.

作者信息

Wu Yan, Tian Yan, Xu Jinhua, Zhong Shaomin, Wang Ruiyan, Wu Wenyu

机构信息

Peking University First Hospital, Beijing, China.

Air Force General Hospital PLA, Beijing, China.

出版信息

J Cosmet Dermatol. 2020 Jul;19(7):1627-1635. doi: 10.1111/jocd.13221. Epub 2019 Nov 26.

DOI:10.1111/jocd.13221
PMID:31769596
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7318129/
Abstract

BACKGROUND

Patients are increasingly aware of the aesthetic appearance of aging hands.

AIMS

To evaluate efficacy and safety of a hyaluronic acid gel for improving skin quality in aged skin of the dorsal hand.

METHODS

This was a 15-month randomized, multi-center, evaluator-blinded, split-hand, no treatment-controlled study. Three treatments with hyaluronic acid gel were administered in the same hand in adult Chinese subjects with grade 2 or 3 (mild or moderate aging) on the Hand Grading Scale (HGS). The primary objective was to evaluate the difference at 3 months between treated and untreated hands, based on the blinded evaluator's HGS assessment. Secondary assessments included the Global Aesthetic Improvement Scale (GAIS), biophysical measurements (skin elasticity, skin roughness and hydration), and subject satisfaction. Safety was evaluated by incidence of adverse events.

RESULTS

A total of 100 subjects were enrolled. Clinically relevant differences in HGS favored HA gel (P < .0001). At 15 months, 87%-96% of treated hands were still improved according to GAIS (per evaluator and subject, respectively). Objective measures of skin quality improved, confirmed by evaluators and highly satisfied subjects. Treatment was well tolerated.

CONCLUSIONS

Hyaluronic acid treatment improved skin quality and reduced the aging appearance of the hand, with high subject satisfaction.

摘要

背景

患者越来越关注衰老手部的美观。

目的

评估透明质酸凝胶改善手背老年皮肤质量的有效性和安全性。

方法

这是一项为期15个月的随机、多中心、评估者盲法、双手对照、无治疗对照研究。对中国成年手部分级量表（HGS）评分为2级或3级（轻度或中度衰老）的受试者，在同一只手上进行三次透明质酸凝胶治疗。主要目的是根据盲法评估者的HGS评估，评估治疗3个月时治疗手与未治疗手之间的差异。次要评估包括整体美学改善量表（GAIS）、生物物理测量（皮肤弹性、皮肤粗糙度和水合作用）以及受试者满意度。通过不良事件发生率评估安全性。

结果

共纳入100名受试者。HGS的临床相关差异有利于透明质酸凝胶（P <.0001）。在15个月时，根据GAIS（分别由评估者和受试者评估），87%-96%的治疗手仍有改善。评估者和高度满意的受试者证实皮肤质量的客观指标有所改善。治疗耐受性良好。

结论

透明质酸治疗改善了皮肤质量，减少了手部的衰老外观，受试者满意度高。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/7318129/1f3489294b62/JOCD-19-1627-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/7318129/fb218db03d36/JOCD-19-1627-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/7318129/6ca43ed3f808/JOCD-19-1627-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/7318129/b128bfc28b6a/JOCD-19-1627-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/7318129/2a084bcd28f8/JOCD-19-1627-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/7318129/76e6d4c1d68b/JOCD-19-1627-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/7318129/8a4fc4f022f2/JOCD-19-1627-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/7318129/1f3489294b62/JOCD-19-1627-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/7318129/fb218db03d36/JOCD-19-1627-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/7318129/6ca43ed3f808/JOCD-19-1627-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/7318129/b128bfc28b6a/JOCD-19-1627-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/7318129/2a084bcd28f8/JOCD-19-1627-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/7318129/76e6d4c1d68b/JOCD-19-1627-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/7318129/8a4fc4f022f2/JOCD-19-1627-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ea81/7318129/1f3489294b62/JOCD-19-1627-g008.jpg

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