从与链霉菌奥利沃西亚 SCSIO LO13 相关的 Onchidium sp.中分离到的新 Borrelidins
New Borrelidins from Onchidium sp. Associated Streptomyces olivaceus SCSIO LO13.
机构信息
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou, 510301, P. R. China.
College of Oceanography, University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.
出版信息
Chem Biodivers. 2020 Jan;17(1):e1900560. doi: 10.1002/cbdv.201900560. Epub 2019 Dec 18.
Borrelidins M-O (1-3), along with four previously known family members (4-7), were isolated from marine pulmonated mollusks Onchidium sp. associated Streptomyces olivaceus SCSIO LO13. The structures of 1-3 were elucidated by extensive spectral analyses of HR-ESI-MS, 1D and 2D NMR data. In addition, the cytotoxic and antibacterial activities of 1-7 were evaluated enabling us to propose some tentative structure-activity relationships (SARs), especially those involving modifications at C(22) and the moieties at C(7) and C(8) of the borrelidin scaffold.
Borrelidins M-O (1-3)，与四个先前已知的家族成员（4-7）一起，从海洋有肺软体动物 Onchidium sp. 相关的链霉菌 SCSIO LO13 中分离得到。通过 HR-ESI-MS、1D 和 2D NMR 数据的广泛光谱分析，阐明了 1-3 的结构。此外，还评估了 1-7 的细胞毒性和抗菌活性，使我们能够提出一些暂定的结构-活性关系（SARs），特别是涉及到在 Borrelidin 支架的 C(22)和 C(7)和 C(8)位进行修饰的那些。
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