支气管哮喘患者支气管肺泡灌洗术中嗜酸性白细胞及芳基硫酸酯酶活性

Eosinophilic leucocytes and arylsulfatase activity in bronchoalveolar lavage fluid of patients with bronchial asthma.

作者信息

Tanizaki Y, Sudo M, Kitani H, Araki H, Oki K, Tsuji M, Takahashi K, Kimura I

机构信息

Department of Medicine, Misasa Medical Branch, Okayama University Medical School, Japan.

出版信息

Acta Med Okayama. 1988 Aug;42(4):227-30. doi: 10.18926/AMO/30993.

DOI:10.18926/AMO/30993

PMID:3177008

Abstract

The arylsulfatase activity and histamine concentration of bronchoalveolar lavage fluid (BALF) were examined in patients with bronchial asthma in relation to the eosinophil count and asthma type (atopic and non-atopic). The BALF arylsulfatase activity and histamine concentration were significantly higher in atopic asthmatics than in non-atopic asthmatics. In atopic asthmatics, the activity of arylsulfatase was significantly increased in patients with a higher eosinophil count (10% or more). However, the BALF histamine concentration did not correlate with the eosinophil count. In non-atopic asthmatics, there was no significant correlation between arylsulfatase activity and the eosinophil count. The results show that arylsulfatase participates in IgE-mediated allergic reactions.

摘要

对支气管哮喘患者的支气管肺泡灌洗液（BALF）中的芳基硫酸酯酶活性和组胺浓度进行了检测，并与嗜酸性粒细胞计数及哮喘类型（特应性和非特应性）相关联。特应性哮喘患者的BALF芳基硫酸酯酶活性和组胺浓度显著高于非特应性哮喘患者。在特应性哮喘患者中，嗜酸性粒细胞计数较高（10%或更高）的患者芳基硫酸酯酶活性显著增加。然而，BALF组胺浓度与嗜酸性粒细胞计数无关。在非特应性哮喘患者中，芳基硫酸酯酶活性与嗜酸性粒细胞计数之间无显著相关性。结果表明，芳基硫酸酯酶参与IgE介导的过敏反应。