School of Basic Medical Sciences, Chengdu University of Traditional Chinese Medicine.
School of Medical Information Engineering, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan Province, China.
Medicine (Baltimore). 2021 Jan 29;100(4):e24200. doi: 10.1097/MD.0000000000024200.
Diabetic peripheral neuropathy (DPN) is 1 of the most common clinical complications of diabetes, which seriously affects the quality of life of patients and causes a substantial economic burden on diabetes care. The pathogenesis of DPN is complex. There is no targeted treatment method, and mainstream treatment methods have low efficacy and large side effects. Traditional Chinese medicine has rich clinical experience in the prevention and treatment of diabetic peripheral neuropathy, which has dramatically improved the quality of life of patients. It is clinically proven that traditional Chinese medicine fumigants (TCMF) have apparent effects in treating diabetic peripheral neuropathy. Therefore, we aim to systematically review the effectiveness and safety of TCMF for DPN.
We will search the following databases: PubMed, Embase, Cochrane Library, MEDLINE, the China National Knowledge Infrastructure, the Chinese Biomedical Literature Database, Cqvip Database, and Wanfang Data. Besides, we will also search for clinical trial registrations, potential grey literature, relevant conference abstracts, and reference lists of established studies. The studies published from the inception of the database to November 2020 will be retrieved. The randomized controlled trials on TCMF for DPN will be included. Also, we will search for clinical trial registrations, potential grey literature, relevant conference abstracts, and reference lists of established studies. The main result is clinical efficacy and nerve conduction velocity. Fasting blood glucose, 2 hours postprandial blood glucose, blood lipid, glycosylated hemoglobin, and adverse events are secondary results. We will perform the analyses using RevMan V.5.3 software.
This study will provide a high-quality comprehensive evaluation of the efficacy and safety of TCMF in the treatment of DPN.
This systematic review will evaluate the effectiveness and safety of TCMF in the treatment of DPN, and provide the latest evidence for clinical application.
INPLASY2020110137.
糖尿病周围神经病变（DPN）是糖尿病最常见的临床并发症之一，严重影响患者的生活质量，并给糖尿病治疗带来沉重的经济负担。DPN 的发病机制复杂，目前尚无针对性的治疗方法，主流治疗方法疗效低，副作用大。中医药在防治糖尿病周围神经病变方面具有丰富的临床经验，显著提高了患者的生活质量。临床研究证实，中药熏剂（TCMF）治疗糖尿病周围神经病变具有明显疗效。因此，我们旨在系统评价 TCMF 治疗 DPN 的有效性和安全性。
我们将检索以下数据库：PubMed、Embase、Cochrane 图书馆、MEDLINE、中国知网、中国生物医学文献数据库、维普数据库、万方数据。此外，我们还将检索临床试验注册、潜在灰色文献、相关会议摘要以及已建立研究的参考文献。检索时间为数据库建立至 2020 年 11 月。纳入 TCMF 治疗 DPN 的随机对照试验。我们还将检索临床试验注册、潜在灰色文献、相关会议摘要以及已建立研究的参考文献。主要结果为临床疗效和神经传导速度。空腹血糖、餐后 2 小时血糖、血脂、糖化血红蛋白和不良反应为次要结果。我们将使用 RevMan V.5.3 软件进行分析。
本研究将对 TCMF 治疗 DPN 的疗效和安全性进行高质量的综合评价。
本系统评价将评估 TCMF 治疗 DPN 的有效性和安全性，为临床应用提供最新证据。
INPLASY 注册号：INPLASY2020110137。
