Nishio S, Yoshihara H
Department of Urology, Seichokai Fuchu Hospital.
Hinyokika Kiyo. 1988 May;34(5):937-42.
Clinical efficacy of ceftriaxone (CTRX) against complicated urinary tract infections in 20 patients was examined, and the serum CTRX level was also measured in the patients with chronic renal failure (CRF). CTRX was administered at a dose of 1.0 g once a day for 5 to 10 days. The overall clinical efficacy was rated excellent in 4 cases (20%), moderate in 13 cases (65%) and poor in 3 cases (15%) with a total efficacy of 85%. Seventeen out of 27 strains (62.8%) isolated were eradicated after CTRX administration. In the patients with CRF, serum levels were very high and showed a plateau 4 hours after the injection. Furthermore, CTRX may not be removed by usual hemodialysis treatment. There were no severe side effects due to CTRX in these patients.
研究了头孢曲松（CTRX）对20例复杂性尿路感染患者的临床疗效，并对慢性肾衰竭（CRF）患者的血清CTRX水平进行了测定。CTRX的给药剂量为每日1.0 g，持续5至10天。总体临床疗效评定为：优4例（20%），中13例（65%），差3例（15%），总有效率为85%。给药后，分离出的27株菌株中有17株（62.8%）被清除。在CRF患者中，血清水平非常高，注射后4小时达到平稳状态。此外，常规血液透析治疗可能无法清除CTRX。这些患者中未出现因CTRX引起的严重副作用。
