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一种采用指神经切除和同种异体神经移植治疗巨指症的新方法。

A Novel Method of Treatment of Macrodactyly with Digital Nerve Resection and Nerve Allograft.

作者信息

Kobraei Edward M, Dusch Marie N, Meisel Erin M, Stevanovic Milan

机构信息

Department of Orthopedic Surgery, Children's Hospital Los Angeles, University of Southern California Keck School of Medicine, Los Angeles, Calif.

出版信息

Plast Reconstr Surg Glob Open. 2019 Oct 29;7(10):e2483. doi: 10.1097/GOX.0000000000002483. eCollection 2019 Oct.

Abstract

Macrodactyly is a rare and debilitating pediatric hand anomaly that has historically been treated with amputation. Recent advances in our understanding of macrodactyly have increasingly implicated the digital nerve as the underlying cause of the condition. In addition, much progress has been made toward digital salvage in treating macrodactyly. Modern techniques often advocate for digital nerve resection to prevent recurrence and treat the underlying etiology. However, little if any emphasis has been given to sensory reconstruction for purposes of protective sensation and acceptable 2-point discrimination at the volar digital pulp. We report 2 cases of macrodactyly treated with digital nerve resection and nerve allograft reconstruction of large sensory nerve gaps which show early promising sensory outcomes. There remain little if any data on the use of nerve allograft in pediatric populations, and its application in the treatment of macrodactyly. This technique permits digit salvage with the potential for improved sensory outcomes without the donor morbidity of autologous nerve harvest.

摘要

巨指症是一种罕见且使人衰弱的小儿手部畸形,在历史上一直通过截肢进行治疗。近年来,我们对巨指症的认识取得了进展,越来越多地认为指神经是该病症的根本原因。此外,在巨指症的保指治疗方面也取得了很大进展。现代技术通常主张进行指神经切除以防止复发并治疗潜在病因。然而,对于掌侧指腹的保护性感觉和可接受的两点辨别觉的感觉重建几乎没有给予任何重视。我们报告了2例接受指神经切除和大感觉神经缺损神经同种异体移植重建治疗的巨指症病例,这些病例显示出早期良好的感觉结果。关于小儿人群使用神经同种异体移植及其在巨指症治疗中的应用,几乎没有相关数据。该技术能够实现保指,有可能改善感觉结果,且不存在自体神经采集的供体并发症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9a97/6846287/e2fb3303c134/gox-7-e2483-g001.jpg

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