Centro de Biotecnologia e Química Fina - Laboratório Associado, Escola Superior de Biotecnologia, Universidade Católica Portuguesa/Porto, Rua de Diogo Botelho, 1327, 4169-005 Porto, Portugal.
Med Mycol. 2020 Aug 1;58(6):707-720. doi: 10.1093/mmy/myz116.
Dermatophytes are a group of pathogenic fungi that exclusively infect the stratum corneum of the skin, nails, and hair, causing dermatophytosis. Superficial skin infections caused by dermatophytes have increased in the last decades. There are conventional antifungals that treat these infections, such as terbinafine, fluconazole, and others. However, the limitations of these treatments (resistance, side effects and toxicity) along with the increasing over-prescription, the misuse of these antifungals and the high treatment costs led to the search for new, alternative, natural-based antifungal drugs. These have multiple mechanisms of action, which works to their advantage, making it difficult for a fungus to create resistance mechanisms against all of them at the same time. The main objective of this work is to provide a state-of-the-art review on dermatophytes, dermatophytosis, and the existing treatments, both conventional and natural, such as chitosan and essential oils.
皮肤癣菌是一组专性感染皮肤角质层、指甲和毛发的致病真菌，可引起皮肤癣病。过去几十年中，皮肤癣菌引起的浅部皮肤感染有所增加。目前有一些常规的抗真菌药物可用于治疗这些感染，如特比萘芬、氟康唑等。然而，这些治疗方法存在局限性（耐药性、副作用和毒性），再加上过度处方、这些抗真菌药物的滥用以及高昂的治疗费用，促使人们寻找新的、替代的、基于天然的抗真菌药物。这些药物具有多种作用机制，这是它们的优势所在，使得真菌很难同时对所有这些机制产生耐药性。本研究的主要目的是提供有关皮肤癣菌、皮肤癣病以及现有治疗方法（包括常规治疗和天然治疗，如壳聚糖和精油）的最新综述。
