Department of Psychiatry and Psychotherapy, University Hospital of Leipzig, Leipzig, Germany.
Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, University Hospital, Goethe University Frankfurt, Frankfurt, Germany.
Eur Arch Psychiatry Clin Neurosci. 2020 Dec;270(8):1073-1076. doi: 10.1007/s00406-019-01085-y. Epub 2019 Nov 26.
We investigated whether baseline brain arousal instability during resting state EEG, using the Vigilance Algorithm Leipzig (VIGALL 2.1), can predict response to methylphenidate therapy in adult ADHD patients. An arousal stability score of the EEGs of 28 adult ADHD patients was calculated quantifying the extent of arousal decline. In logistic regression analysis, arousal stability score predicted response to MPH [odds ratio 1.28 (95% CI 1.0-1.65); p = 0.027]. In this pilot study, we demonstrated that arousal stability at baseline predicted methylphenidate treatment response, indicating that less stable arousal regulation during a 15-min EEG at rest increases the chance of treatment response.
我们研究了使用莱比锡警觉算法（VIGALL 2.1）在静息状态 EEG 中基线大脑警觉不稳定是否可以预测成人 ADHD 患者对哌醋甲酯治疗的反应。通过量化警觉下降程度，计算了 28 名成人 ADHD 患者的 EEG 警觉稳定性评分。在逻辑回归分析中，警觉稳定性评分预测了 MPH 的反应[优势比 1.28（95%可信区间 1.0-1.65）；p=0.027]。在这项初步研究中，我们证明了基线时的警觉稳定性可以预测哌醋甲酯治疗的反应，表明在 15 分钟的静息 EEG 中警觉调节稳定性较低会增加治疗反应的机会。
