Loo S K, Teale P D, Reite M L
Department of Psychiatry, University of Colorado Health Sciences Center, Denver 80262, USA.
Biol Psychiatry. 1999 Jun 15;45(12):1657-60. doi: 10.1016/s0006-3223(98)00250-9.
Recent electrophysiologic studies have found fairly consistent differences between children with attention-deficit/hyperactivity disorder (ADHD) and age-matched control subjects. The present study examined electroencephalogram (EEG) changes associated with a double blind, placebo-controlled administration of methylphenidate among children with ADHD.
Subjects were 10 children, ages 8 to 13, with a primary diagnosis of ADHD. Brain electrical activity was recorded with 7 electrodes in the frontal, central, and midline areas during baseline and cognitive activation conditions.
Repeated-measures ANOVAs indicate that children exhibiting a positive medication response had reductions of theta and alpha as well as increased beta in the frontal regions, while nonresponders showed the opposite pattern (p < .05). Significant correlations between improvement on a vigilance task and changes in beta activity in the frontal electrodes emerged as well.
These preliminary findings indicate that there are different electrophysiologic correlates to methylphenidate among ADHD children who are medication responders and nonresponders.
近期的电生理研究发现，患有注意力缺陷多动障碍（ADHD）的儿童与年龄匹配的对照受试者之间存在相当一致的差异。本研究考察了在ADHD儿童中，与哌甲酯双盲、安慰剂对照给药相关的脑电图（EEG）变化。
受试者为10名年龄在8至13岁之间、初步诊断为ADHD的儿童。在基线和认知激活状态下，用7个电极记录额叶、中央和中线区域的脑电活动。
重复测量方差分析表明，表现出阳性药物反应的儿童额叶区域的θ波和α波减少，β波增加，而无反应者则呈现相反的模式（p < .05）。警觉任务改善与额叶电极β活动变化之间也出现了显著相关性。
这些初步研究结果表明，在ADHD儿童中，药物反应者和无反应者对哌甲酯的电生理相关性不同。
