Department of Epidemiology, School of Public Health, The Key Laboratory of Public Health Safety of Ministry of Education, Fudan University, Shanghai, China.
Key Laboratory of Health Technology Assessment of Ministry of Health, Fudan University, Shanghai, China.
Curr HIV/AIDS Rep. 2019 Dec;16(6):439-447. doi: 10.1007/s11904-019-00473-2.
The last 15 years have witnessed a dramatic change in HIV-related epidemiology amidst improvements in treatment and care in China. With proper treatment, HIV is now considered a chronic disease. As a consequence, many people living with HIV (PLWH) now present age-related comorbidities. We reviewed 13 topical issues concerning the epidemiology of aging with HIV in mainland China.
Many of aging-related issues associated with the biological and physical aspects of living with HIV addressed in mainland China are consistent with the global literature. Greater prevalence of age-related comorbidities among PLWH was observed. Beyond biological mechanisms associated with HIV infection and traditional risk factors, other factors play a vital role in the aging process among PLWH. A stronger focus on screening, prevention, and management of non-HIV co-morbidities among PLWH is now warranted. Macro-social factors need to be integrated into next generation of clinical and/or behavioral HIV research to inform disease progression and management as well as prevention.
在中国治疗和护理水平不断提高的背景下，过去 15 年，HIV 相关流行病学发生了显著变化。随着治疗得当，HIV 现在被认为是一种慢性病。因此，许多 HIV 感染者（PLWH）现在出现了与年龄相关的合并症。我们回顾了中国大陆 HIV 感染者老龄化相关的 13 个专题问题。
中国大陆 HIV 感染者老龄化相关的许多生物学和身体方面的问题与全球文献一致。PLWH 中年龄相关合并症的患病率更高。除了与 HIV 感染和传统危险因素相关的生物学机制外，其他因素在 PLWH 的衰老过程中也起着至关重要的作用。现在有必要更加关注 PLWH 的非 HIV 合并症的筛查、预防和管理。需要将宏观社会因素纳入下一代 HIV 临床和/或行为研究中，以了解疾病进展和管理以及预防。
