Alcantara A, Brener Z
Acta Trop. 1978 Sep;35(3):209-19.
The uptake and further development of bloodstream forms from T. cruzi Y and CL strains in mouse peritoneal macrophages have been investigated. Parasites from the Y strain (which present predominance of slender forms) are 20 to 30-fold more infective to macrophages than those from CL strain in which stout forms highly predominate. A complete amastigote-trypomastigote cycle is observed in normal or thioglycollate-induced macrophages infected with parasites from both strains.--Opsonization significantly increases the uptake by normal macrophages of parasites from both strains. The fate of the opsonizated parasites is, however, different: the Y trypomastigotes present a normal cycle which culminates with the release of newly formed trypomastigotes whereas CL parasites are extensively destroyed by normal macrophages.--The differences in the uptake and fate displayed by both T. cruzi populations are not well understood. They are apparently related to parasite membrane components or macrophage receptors differences, which are probably influencing endocytosis and the further intracellular development of the parasites.
对克氏锥虫Y株和CL株的血流型在小鼠腹腔巨噬细胞中的摄取及进一步发育进行了研究。Y株的寄生虫（主要呈现细长型）对巨噬细胞的感染性比CL株的寄生虫高20至30倍，CL株中粗壮型高度占主导。在感染了这两种株系寄生虫的正常或巯基乙酸诱导的巨噬细胞中均观察到完整的无鞭毛体-锥鞭毛体循环。调理作用显著增加了正常巨噬细胞对这两种株系寄生虫的摄取。然而，被调理的寄生虫的命运有所不同：Y株锥鞭毛体呈现正常循环，最终释放出新形成的锥鞭毛体，而CL株寄生虫则被正常巨噬细胞大量破坏。两种克氏锥虫群体在摄取和命运上表现出的差异尚未得到充分理解。它们显然与寄生虫膜成分或巨噬细胞受体差异有关，这可能影响内吞作用以及寄生虫在细胞内的进一步发育。
