Matsumoto T, Sarna S K, Condon R E, Dodds W J, Mochinaga N
Department of Surgery, Medical College of Wisconsin, Milwaukee.
Am J Physiol. 1988 Oct;255(4 Pt 1):G409-16. doi: 10.1152/ajpgi.1988.255.4.G409.
We investigated whether the gallbladder has cyclic motor activity similar to that of the stomach, lower esophageal sphincter, and sphincter of Oddi in the fasted state. We found that the canine gallbladder infundibulum exhibited a cyclic burst of short duration (69 +/- 3 s) contractions that were closely associated with phase III activity of the antrum. The cyclic motor activity was sometimes less prominent or absent in the body and the fundus of the gallbladder. The mean period of gallbladder cyclic motor activity was not significantly different from the mean period of phase III activity in the stomach and the duodenum. The cyclic bursts of gallbladder contractions lasted for 21 +/- 2 min. The gallbladder cyclic motor activity started at about the same time as the antral phase III activity, and both of these activities started approximately 12 min earlier than the duodenal phase III activity. In addition to the aforementioned cyclic bursts of contractions, the gallbladder sometimes exhibited long duration (6.4 +/- 0.6 min) contractions that occurred irregularly and unpredictably during the duodenal migrating motor complex cycle. We conclude that during fasting the canine gallbladder has a cyclic motor activity that is temporally related to phase III activity of the stomach and the duodenum. The role of short duration phasic contractions during cyclic motor activity may be to periodically stir gallbladder contents, whereas the long duration contractions may partially empty the gallbladder in the fasted state.
我们研究了在禁食状态下，胆囊是否具有与胃、食管下括约肌和奥迪括约肌类似的周期性运动活动。我们发现犬胆囊漏斗部表现出短持续时间（69±3秒）的周期性收缩爆发，这与胃窦的III期活动密切相关。胆囊体部和底部的周期性运动活动有时不太明显或不存在。胆囊周期性运动活动的平均周期与胃和十二指肠III期活动的平均周期无显著差异。胆囊收缩的周期性爆发持续21±2分钟。胆囊周期性运动活动与胃窦III期活动大约同时开始，且这两种活动均比十二指肠III期活动早约12分钟开始。除了上述周期性收缩爆发外，胆囊有时还会在十二指肠移行性运动复合波周期中出现不规则且不可预测的长时间（6.4±0.6分钟）收缩。我们得出结论，在禁食期间，犬胆囊具有与胃和十二指肠III期活动在时间上相关的周期性运动活动。周期性运动活动期间短持续时间的阶段性收缩的作用可能是周期性地搅动胆囊内容物，而长时间收缩可能在禁食状态下使胆囊部分排空。
