Fiorucci S, Santucci L, Morelli A
Istituto di Gastroenterologia ed Endoscopia Digestiva, University of Perugia, Italy.
Dig Dis Sci. 1993 Dec;38(12):2236-40. doi: 10.1007/BF01299902.
In the present study we evaluated the effect of ondansetron (formerly indicated as GR38032F), a potent and selective type-3 5-hydroxytryptamine receptor antagonist, on erythromycin-induced gallbladder emptying and motilin release, as well as gallbladder emptying induced by a regular meal in healthy volunteers. Gallbladder emptying was evaluated by sonography. Ondansetron, at the dose of 0.05 mg/kg, significantly reduced (P < 0.001 by ANOVA) the gallbladder emptying induced by 2 mg/kg/hr erythromycin, but did not increase basal gallbladder volume or inhibit gallbladder emptying induced by a regular meal. Ondansetron also inhibited the motilin release induced by erythromycin (P < 0.001, by ANOVA). These results suggest that serotoninergic mechanisms modulate the effects of erythromycin on the gastrointestinal tract. The exact site of action of ondansetron remains to be identified.
在本研究中，我们评估了强效选择性5-羟色胺3型受体拮抗剂昂丹司琼（曾用名GR38032F）对健康志愿者中红霉素诱导的胆囊排空和胃动素释放以及正常餐食诱导的胆囊排空的影响。通过超声检查评估胆囊排空情况。0.05mg/kg剂量的昂丹司琼显著降低了（方差分析，P<0.001）2mg/kg/hr红霉素诱导的胆囊排空，但未增加基础胆囊容积，也未抑制正常餐食诱导的胆囊排空。昂丹司琼还抑制了红霉素诱导的胃动素释放（方差分析，P<0.001）。这些结果表明，5-羟色胺能机制调节红霉素对胃肠道的作用。昂丹司琼的确切作用位点尚待确定。
