Forensic Toxicology Laboratory, Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, 4800 SW 35th Drive, Gainesville, FL 32608, USA.
NMS Labs, 200 Welsh Rd, Horsham, PA 19044, USA.
J Anal Toxicol. 2020 Apr 30;44(3):298-300. doi: 10.1093/jat/bkz092.
Between March 2017 and November 2018, 54 prisoner fatal overdose cases submitted to the University of Florida Forensic Toxicology Laboratory involved synthetic cannabinoids including 5F-ADB, FUB-AMB, 5F-AMB, MDMB-FUBINACA and AB-CHMINACA. Analysis of blood and urine samples was performed at NMS Labs (Horsham, PA) by liquid chromatography/tandem mass spectrometry screening, confirmatory and quantitative methods validated according to Scientific Working Group for Forensic Toxicology guidelines. This work highlights the importance of effective communication between toxicologists and medical examiners/coroners, and the value of public-private partnerships to provide coverage while laboratories work to update instrumentation and validate their own new methods to keep up with the challenges of emerging substances.
2017 年 3 月至 2018 年 11 月，提交给佛罗里达大学法医毒理学实验室的 54 例囚犯致命过量用药案例涉及合成大麻素，包括 5F-ADB、FUB-AMB、5F-AMB、MDMB-FUBINACA 和 AB-CHMINACA。NMS 实验室（宾夕法尼亚州霍舍姆）采用液质联用串联质谱筛选法对血液和尿液样本进行分析，根据法医毒理学科学工作组的指南，对确证和定量方法进行了验证。这项工作强调了毒理学家与法医/验尸官之间进行有效沟通的重要性，以及公私合作伙伴关系的价值，即在实验室努力更新仪器设备并验证自己的新方法以应对新出现物质的挑战的同时，提供覆盖范围。
