Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China.
Adv Exp Med Biol. 2019;1182:1-37. doi: 10.1007/978-981-32-9421-9_1.
Ganoderma (Lingzhi) has been used for a long time in China to prevent and treat various diseases. Accumulated studies have demonstrated that the Ganoderma modulates immune function both in vivo and in vitro. The immunomodulating effects of Ganoderma were extensive, including promoting the innate immune function, humoral immunity, and cellular immunity. In particular, G. lucidum polysaccharides may affect immune cells and immune-related cells including B and T lymphocytes, dendritic cells, macrophages, and natural killer cells, with the promotion of immune organ growth, cytokine release, and other immune regulatory functions. Furthermore, cellular and molecular immunomodulatory mechanisms, possible receptors involved, and triggered signaling pathways have also been summarized. However, whole animal experiments are still needed to further establish the mechanism of the immunomodulating effects by Ganoderma. Importantly, evidence-based clinical trials are also needed.
灵芝在中国已经使用了很长时间来预防和治疗各种疾病。积累的研究表明，灵芝在体内和体外都能调节免疫功能。灵芝的免疫调节作用广泛，包括促进先天免疫功能、体液免疫和细胞免疫。特别是，灵芝多糖可能影响免疫细胞和免疫相关细胞，包括 B 和 T 淋巴细胞、树突状细胞、巨噬细胞和自然杀伤细胞，促进免疫器官生长、细胞因子释放和其他免疫调节功能。此外，还总结了细胞和分子免疫调节机制、可能涉及的受体以及触发的信号通路。然而，仍需要进行整体动物实验来进一步确定灵芝免疫调节作用的机制。重要的是，还需要进行基于证据的临床试验。
