Department of Pharmacology, School of Basic Medical Sciences, Peking University, Beijing, China.
Affiliated Hospital of Chengde Medical University, Chengde, Hebei, China.
Adv Exp Med Biol. 2019;1182:39-77. doi: 10.1007/978-981-32-9421-9_2.
The antitumor effect of Ganoderma (Lingzhi) is closely related to immunoregulation. Based on our research and other references, this article discussed the antitumor effect of Ganoderma mediated by immunological mechanism, including promoting the function of mononuclear-macrophages and natural killers; promoting M1-type macrophage polarization vs M2-type; promoting maturation and differentiation of dendritic cells, increasing its antigen presentation, activating lymphocytes and increasing cytotoxicity of cytotoxin T lymphocyte; promoting production of cytokines; and inhibiting tumor escape from immune surveillance. Also, clinical studies with immunological indexes were reviewed.
灵芝的抗肿瘤作用与免疫调节密切相关。基于我们的研究和其他参考文献，本文讨论了灵芝通过免疫机制介导的抗肿瘤作用，包括促进单核-巨噬细胞和自然杀伤细胞的功能；促进 M1 型巨噬细胞极化与 M2 型；促进树突状细胞的成熟和分化，增加其抗原呈递，激活淋巴细胞，增加细胞毒性 T 淋巴细胞的细胞毒性；促进细胞因子的产生；以及抑制肿瘤逃避免疫监视。此外，还对免疫指标的临床研究进行了综述。
