Biruete Annabel, Allen Jacob M, Kistler Brandon M, Jeong Jin Hee, Fitschen Peter J, Swanson Kelly S, Wilund Kenneth R
Division of Nutritional Sciences, University of Illinois at Urbana-Champaign.
Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign.
Top Clin Nutr. 2019 Apr-Jun;34(2):153-160. doi: 10.1097/TIN.0000000000000170.
The gut microbiota has been implicated in the pathogenesis and progression of kidney disease. However, little is known about the gut microbiota in hemodialysis (HD) patients. We assessed the gut microbiota and its relationship with clinical variables in ten HD patients. We found that the -to- ratio was positively associated with traditional risk factors for cardiovascular disease. Furthermore, was positively associated with carbohydrate intake and negatively associated with arterial stiffness. Finally, endotoxemia was inversely associated with butyrate producers. Future studies should assess if targeting the gut microbiota result in a lower burden for cardiovascular disease in HD patients.
肠道微生物群已被认为与肾脏疾病的发病机制和进展有关。然而，对于血液透析（HD）患者的肠道微生物群知之甚少。我们评估了10名HD患者的肠道微生物群及其与临床变量的关系。我们发现，-与-的比值与心血管疾病的传统危险因素呈正相关。此外，与碳水化合物摄入量呈正相关，与动脉僵硬度呈负相关。最后，内毒素血症与丁酸盐产生菌呈负相关。未来的研究应评估针对肠道微生物群是否会降低HD患者的心血管疾病负担。
