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印度尼西亚棉兰市接受抗逆转录病毒治疗的艾滋病毒/艾滋病患者焦虑和抑郁相关CD4细胞计数筛查

Screening of Anxiety and Depression Related CD4 Count of People Living with HIV/AIDS with Anti-Retroviral in Medan, Indonesia.

作者信息

Agus Dona Farila, Effendy Elmeida, Camellia Vita

机构信息

Department of Psychiatry, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia.

出版信息

Open Access Maced J Med Sci. 2019 Aug 20;7(16):2590-2594. doi: 10.3889/oamjms.2019.396. eCollection 2019 Aug 30.

Abstract

BACKGROUND

HIV, which causes AIDS, infects the immune system cells, by destroying or damaging the function of the CD4. PLWHA will have twice the risk of experiencing mental health disorders such as depression and anxiety compared with the general population, thereby suppressing immune function, decreasing their quality of life, decreasing the level of adherence to treatment, and contributing significantly to the occurrence of premature death.

AIM

To determine the correlation Anxiety and Depression symptoms and CD4 levels in PLWHA who are undergoing Anti-Retroviral treatment at the HIV/AIDS.

METHODS

The study was a cross-sectional study, which assesses the correlation between Hospital Anxiety and Depression Scale scores (HADS) and CD4 levels in PLWHA who are receiving ARV in the HIV/AIDS Special Services Polyclinic Medan Haji general hospital.

RESULTS

It was found that the average HADS-A score, PLWHA was 15.286 and the SD ± 2.244. This shows that PLWHA is in moderate to severe anxiety and moderate to severe depression. The mean CD4 level of people with HIV/AIDS/PLWHA was 288.171 and SD ± 88.955. According to WHO criteria, regarding the classification of HIV immunodeficiency in adults, are classified as moderate immunodeficiency. There was a significant correlation between the HADS-A score and CD4 level with a correlation value of r = -0.592 indicating a negative correlation with a moderate correlation strength, and the correlation between HADS-D score and CD4 level. The strength of the relationship between HADS-D score and CD4 level is r = -0.650, shows a negative correlation with strong correlation strength.

CONCLUSION

from this study, it was found that there is a relationship between depression and anxiety symptom and CD4 level.

摘要

背景

导致艾滋病的艾滋病毒通过破坏或损害CD4的功能来感染免疫系统细胞。与普通人群相比,艾滋病病毒感染者出现抑郁症和焦虑症等心理健康障碍的风险会高出两倍,从而抑制免疫功能,降低生活质量,降低治疗依从性,并显著增加过早死亡的发生率。

目的

确定在接受抗逆转录病毒治疗的艾滋病病毒感染者中,焦虑和抑郁症状与CD4水平之间的相关性。

方法

该研究为横断面研究,评估棉兰哈吉综合医院艾滋病专科门诊接受抗逆转录病毒治疗的艾滋病病毒感染者的医院焦虑抑郁量表(HADS)评分与CD4水平之间的相关性。

结果

发现艾滋病病毒感染者的HADS-A平均得分为15.286,标准差±2.244。这表明艾滋病病毒感染者处于中度至重度焦虑和中度至重度抑郁状态。艾滋病病毒感染者/艾滋病患者的平均CD4水平为288.171,标准差±88.955。根据世界卫生组织关于成人艾滋病毒免疫缺陷分类的标准,被归类为中度免疫缺陷。HADS-A评分与CD4水平之间存在显著相关性,相关值r = -0.592,表明呈负相关且相关性强度为中等,HADS-D评分与CD4水平之间也存在相关性。HADS-D评分与CD4水平之间的关系强度为r = -0.650,表明呈负相关且相关性强度较强。

结论

从本研究发现,抑郁和焦虑症状与CD4水平之间存在关联。

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