Hamaguchi Y, Juhn S K, Sakakura Y
Department of Otolaryngology, University of Minnesota, School of Medicine, Minneapolis.
Am J Otolaryngol. 1988 May-Jun;9(3):111-6. doi: 10.1016/s0196-0709(88)80016-4.
Reduced glutathione (GSH), a potential factor in the chronicity of human otitis media, was tested to determine its potency in the recurrence of antigen-induced otitis media in chinchillas sensitized with human serum albumin (HSA). GSH instillation into the healing middle ear bulla reproduced a level of otitis media similar to the original antigen-induced otitis media with cellular involvement occurring earlier, according to cytologic analyses. This study indicates that GSH is probably a factor in recurrent antigen-induced otitis media, controlling the balance between thiol proteases and thiol protease inhibitors during middle ear inflammation.
还原型谷胱甘肽（GSH）是人类中耳炎慢性化的一个潜在因素，我们对其在用人血清白蛋白（HSA）致敏的龙猫抗原诱导性中耳炎复发中的作用进行了测试。根据细胞学分析，向愈合中的中耳鼓泡滴注GSH可重现与最初抗原诱导性中耳炎相似程度的中耳炎，且细胞参与出现得更早。本研究表明，GSH可能是抗原诱导性中耳炎复发的一个因素，在中耳炎症期间控制硫醇蛋白酶和硫醇蛋白酶抑制剂之间的平衡。
