CDD/SPARCLE：2020 年的保守结构域数据库。
CDD/SPARCLE: the conserved domain database in 2020.
机构信息
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bldg. 38 A, Room 8N805, 8600 Rockville Pike, Bethesda, MD 20894, USA.
出版信息
Nucleic Acids Res. 2020 Jan 8;48(D1):D265-D268. doi: 10.1093/nar/gkz991.
As NLM's Conserved Domain Database (CDD) enters its 20th year of operations as a publicly available resource, CDD curation staff continues to develop hierarchical classifications of widely distributed protein domain families, and to record conserved sites associated with molecular function, so that they can be mapped onto user queries in support of hypothesis-driven biomolecular research. CDD offers both an archive of pre-computed domain annotations as well as live search services for both single protein or nucleotide queries and larger sets of protein query sequences. CDD staff has continued to characterize protein families via conserved domain architectures and has built up a significant corpus of curated domain architectures in support of naming bacterial proteins in RefSeq. These architecture definitions are available via SPARCLE, the Subfamily Protein Architecture Labeling Engine. CDD can be accessed at https://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml.
随着 NLM 的保守域数据库 (CDD) 作为一个公开可用的资源进入其 20 年的运营，CDD 编目人员继续开发广泛分布的蛋白质域家族的层次分类，并记录与分子功能相关的保守位点，以便将它们映射到用户查询中，以支持基于假设的生物分子研究。CDD 提供了预先计算的域注释档案，以及对单个蛋白质或核苷酸查询以及更大的蛋白质查询序列集的实时搜索服务。CDD 工作人员通过保守域结构继续对蛋白质家族进行特征描述，并构建了大量经过编目的域结构，以支持在 RefSeq 中命名细菌蛋白质。这些架构定义可通过 SPARCLE（子家族蛋白质架构标记引擎）获得。可以在 https://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml 访问 CDD。
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