Institute of Molecular Life Sciences, University of Zürich, Switzerland.
Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI, USA.
FEBS Lett. 2019 Dec;593(24):3649-3659. doi: 10.1002/1873-3468.13699. Epub 2019 Dec 6.
Small laboratory animals are powerful models for investigating in vivo viral pathogenesis of a number of viruses. For adenoviruses (AdVs), however, species-specificity poses limitations to studying human adenoviruses (HAdVs) in mice and other small laboratory animals. Thus, this review covers work on naturally occurring mouse AdVs, primarily mouse adenovirus type 1 (MAdV-1), a member of the species Murine mastadenovirus A. Molecular genetics, virus life cycle, cell and tissue tropism, interactions with the host immune response, persistence, and host genetics of susceptibility are described. A brief discussion of MAdV-2 (member of species Murine mastadenovirus B) and MAdV-3 (member of species Murine mastadenovirus C) is included. We report the use of MAdVs in the development of vectors and vaccines.
小型实验动物是研究多种病毒体内病毒发病机制的有力模型。然而，对于腺病毒（AdV）来说，种属特异性限制了在小鼠和其他小型实验动物中研究人类腺病毒（HAdV）。因此，本综述涵盖了对天然存在的小鼠 AdV 的研究，主要是小鼠腺病毒 1 型（MAdV-1），它是 A 种鼠巨细胞病毒的成员。本文描述了分子遗传学、病毒生命周期、细胞和组织嗜性、与宿主免疫反应的相互作用、持续性以及宿主易感性的遗传特性。还简要讨论了 MAdV-2（B 种鼠巨细胞病毒的成员）和 MAdV-3（C 种鼠巨细胞病毒的成员）。我们报告了 MAdV 在载体和疫苗开发中的应用。
