一项在印度东部一家三级护理中心进行的观察性前瞻性研究，旨在评估新诊断的肾移植后糖尿病（NODAT）的结局。

An observational prospective study to evaluate the outcomes of new onset diabetes after renal transplantation (NODAT) in a tertiary care centre in eastern India.

机构信息

Department of Nephrology, Rabindranath Tagore International Institute of Cardiac Sciences, EM Bypass, Kolkata, West Bengal, India.

Department of Nephrology, Rabindranath Tagore International Institute of Cardiac Sciences, EM Bypass, Kolkata, West Bengal, India; Department of Endocrinology, KPC Medical College, Jadavpur, Kolkata, West Bengal, India.

出版信息

Diabetes Res Clin Pract. 2020 Jan;159:107948. doi: 10.1016/j.diabres.2019.107948. Epub 2019 Nov 26.

DOI:10.1016/j.diabres.2019.107948

PMID:31778745

Abstract

AIM

To analyse post-transplant outcomes of NODAT patients in comparison to the regular cohort (non-NODAT).

OBJECTIVES

To compare graft survival and rejection rate, patient survival rate, incidence of hospitalization (due to any cause) in between NODAT and non-NODAT groups in cases of renal transplantation.

METHODS

A single-centred prospective real-world observational study of 100 subjects who underwent renal transplantation over a period of two years. All NODAT cases evaluated for graft survival/rejection, incidence of hospitalisation/infection, mortality from all causes and compared with that of non-NODAT post-transplant recipients. Nominal categorical data between the groups are compared using Chi-square test or Fisher's exact test as appropriate. p value < 0.05 was taken to indicate a significant difference.

RESULTS

Mean number of hospital admissions of subjects was 1.38 ± 1.38 and 0.29 ± 0.56 in NODAT and Non-NODAT respectively, p < 0.0001. Nineteen out of 24 NODAT subjects and 72 out of 76 Non-NODAT subjects had graft survival, p = 0.0342. Twenty out of 24 NODAT and 74 out of 76 Non-NODAT subjects had survived, p = 0.0282.

CONCLUSIONS

NODAT leads to adverse outcomes viz. increased rate of hospitalization, reduced rates of allograft survival and patient survival.

摘要

目的

分析 NODAT 患者与常规队列（非 NODAT）移植后的结果。

目的

比较肾移植后 NODAT 和非 NODAT 组之间的移植物存活率和排斥率、患者存活率、因任何原因住院的发生率。

方法

一项为期两年的 100 例接受肾移植的单中心前瞻性真实世界观察性研究。对所有 NODAT 病例进行评估，以评估移植物存活率/排斥率、住院/感染发生率、全因死亡率，并与非 NODAT 移植受者进行比较。使用卡方检验或 Fisher 确切检验比较两组之间的名义分类数据。p 值<0.05 表示差异具有统计学意义。

结果

NODAT 组和非 NODAT 组的受试者平均住院次数分别为 1.38±1.38 和 0.29±0.56，p<0.0001。24 例 NODAT 患者中有 19 例和 76 例非 NODAT 患者有移植物存活，p=0.0342。24 例 NODAT 患者中有 20 例和 76 例非 NODAT 患者存活，p=0.0282。