Deblanc Céline, Oger Aurélie, Simon Gaëlle, Le Potier Marie-Frédérique
ANSES, Ploufragan-Plouzané-Niort Laboratory, Swine Virology Immunology Unit, National Reference Laboratory and OIE Reference Laboratory for Aujeszky's Disease, 22440 Ploufragan, France.
Pathogens. 2019 Nov 26;8(4):266. doi: 10.3390/pathogens8040266.
Pseudorabies (PR), also known as Aujeszky's disease, is an economically important disease for the pig industry. It has been eradicated in domestic pigs in many European countries, including France, but its causative agent-Suid Herpesvirus 1-is still circulating in wild boars. The risk of endemic PR in wild fauna lies in reintroducing the virus among domestic pigs and transmitting it to other mammals, especially hunting dogs for which the disease is rapidly fatal. As such infections are regularly reported in France, this study genetically characterized canine PR virus strains in the country to obtain information on their diversity and evolution. Partial sequencing of the glycoprotein C-encoding gene from 55 virus strains isolated from dogs between 2006 and 2018 showed that 14 strains belonged to genotype I-clade A and another 38 to genotype I-clade B, two clades usually reported in Western Europe. More surprisingly, three strains were found to belong to genotype II, suggesting an Asian origin. Genotype I-clade A strains exhibited the highest diversity as five geographically segregated genogroups were identified.
伪狂犬病（PR），也称为奥耶斯基氏病，是对养猪业具有重要经济影响的一种疾病。在包括法国在内的许多欧洲国家，家猪中已根除了该疾病，但其病原体——猪疱疹病毒1型——仍在野猪中传播。野生动物中地方性伪狂犬病的风险在于将病毒重新引入家猪群体并传播给其他哺乳动物，尤其是猎犬，这种疾病对猎犬来说会迅速致命。由于法国经常报告此类感染病例，本研究对该国犬类伪狂犬病病毒株进行了基因特征分析，以获取有关其多样性和进化的信息。对2006年至2018年间从犬类分离出的55株病毒株的糖蛋白C编码基因进行部分测序，结果显示，14株属于I型-A分支，另外38株属于I型-B分支，这两个分支通常在西欧被报道。更令人惊讶的是，发现3株属于II型，表明其起源于亚洲。I型-A分支的病毒株表现出最高的多样性，因为鉴定出了5个地理隔离的基因群。
