Askari Alireza, Hasheminasab Fatemeh Sadat, Sadeghpour Omid, Naghizadehd Mohammad Mehdi, Ravansalar Seyed Ali, Iraji Aida, Hashempur Mohammad Hashem
Bone and Joint Reconstruction Research Center, Shafa Orthopedic Hospital, Iran University of Medical Sciences, Tehran, Iran.
Pharmacology Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Front Pharmacol. 2024 May 6;15:1377527. doi: 10.3389/fphar.2024.1377527. eCollection 2024.
Basil is a widely used herb in Persian medicine and is gaining recognition as a functional food worldwide.
This trial aimed to assess the effectiveness of a traditional formulation of basil oil in comparison with diclofenac gel in treating knee osteoarthritis, considering its established anti-inflammatory, anti-nociceptive, and anti-oxidative properties.
One hundred eligible patients were equally randomized to the traditional basil oil (containing sesame oil) and diclofenac gel groups. They used their respective topical treatments thrice daily for 4 weeks. Various measurements were taken at the beginning of the study, 2, and 4 weeks after starting the intervention, including the 8-m walk test, knee pain (based on visual analog scale), flexion angle of the knee joint, analgesic consumption, and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) questionnaire.
No significant differences were observed between the basil oil and diclofenac gel groups in any of the measured outcomes. However, significant improvements were noted within each group for most variables.
Topical application of the traditional formulation of basil oil appears to improve clinical symptoms and certain functional indicators of knee osteoarthritis to a similar extent as diclofenac gel. This suggests that basil oil could be considered an effective management option for this condition. https://irct.behdasht.gov.ir/, identifier IRCT2017081711341N7.
罗勒是波斯医学中广泛使用的一种草药，并且在全球范围内作为一种功能性食品而日益受到认可。
本试验旨在评估罗勒油传统配方与双氯芬酸凝胶相比在治疗膝骨关节炎方面的有效性，鉴于其已确定的抗炎、抗伤害感受和抗氧化特性。
100名符合条件的患者被随机分为罗勒油（含芝麻油）传统配方组和双氯芬酸凝胶组，每组人数相等。他们每天使用各自的局部治疗药物三次，持续4周。在研究开始时、开始干预后2周和4周进行了各种测量，包括8米步行试验、膝关节疼痛（基于视觉模拟评分）、膝关节屈曲角度、镇痛药使用量以及西安大略和麦克马斯特大学骨关节炎指数（WOMAC）问卷。
罗勒油组和双氯芬酸凝胶组在任何测量结果中均未观察到显著差异。然而，每组中大多数变量均有显著改善。
罗勒油传统配方的局部应用似乎在改善膝骨关节炎的临床症状和某些功能指标方面与双氯芬酸凝胶达到相似程度。这表明罗勒油可被视为该病症的一种有效治疗选择。https://irct.behdasht.gov.ir/，标识符IRCT2017081711341N7。
