Zhang Dingding, Yan Huiying, Wei Yongxiang, Liu Xiangyu, Zhuang Zong, Dai Wei, Li Jinsong, Li Wei, Hang Chunhua
Department of Neurosurgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.
Front Neurol. 2019 Nov 12;10:1186. doi: 10.3389/fneur.2019.01186. eCollection 2019.
The purpose of the present study was to determine if C-reactive protein (CRP)/albumin ratio was associated with disease severity and unfavorable outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). One hundred and twenty-three consecutive patients suffering from aSAH were included in the study, which was carried out during the period of June 2016 to September 2018. Clinical and demographic parameters were recorded. CRP and albumin assessments were conducted upon admission. The association of CRP/albumin ratio with the disease severity and 3-month outcomes was evaluated. Higher CRP/albumin ratio was significantly associated with a higher World Federation of Neurological Surgeons Scale (WFNS) grade ( < 0.05). Poor outcome at 3 months was associated with a higher WFNS grade, higher serum glucose, higher CRP level, lower albumin level, higher Fisher score, higher CRP/albumin ratio, symptomatic cerebral vasospasm, intraventricular hemorrhage, delayed cerebral ischemia, and age using univariate analysis. The multivariate binary regression analysis revealed that the CRP/albumin ratio was independently associated with unfavorable outcomes after adjustment for age, WFNS grade, serum glucose, albumin, Fisher score, symptomatic cerebral vasospasm, intraventricular hemorrhage, and delayed cerebral ischemia. Elevated CRP/albumin ratio was associated with disease severity and poor outcomes after aSAH.
本研究的目的是确定C反应蛋白（CRP）/白蛋白比值是否与动脉瘤性蛛网膜下腔出血（aSAH）患者的疾病严重程度及不良预后相关。本研究纳入了123例连续的aSAH患者，研究于2016年6月至2018年9月期间进行。记录了临床和人口统计学参数。入院时进行了CRP和白蛋白评估。评估了CRP/白蛋白比值与疾病严重程度及3个月预后的相关性。较高的CRP/白蛋白比值与较高的世界神经外科医师联合会分级（WFNS分级）显著相关（<0.05）。单因素分析显示，3个月时的不良预后与较高的WFNS分级、较高的血糖、较高的CRP水平、较低的白蛋白水平、较高的Fisher评分、较高的CRP/白蛋白比值、症状性脑血管痉挛、脑室内出血、迟发性脑缺血及年龄相关。多因素二元回归分析显示，在对年龄、WFNS分级、血糖、白蛋白、Fisher评分、症状性脑血管痉挛、脑室内出血及迟发性脑缺血进行校正后，CRP/白蛋白比值与不良预后独立相关。aSAH后CRP/白蛋白比值升高与疾病严重程度及不良预后相关。
