Department of Obstetrics and Gynecology, National University Hospital, National University of Singapore, Singapore, 119228, Singapore.
Departments of Epidemiology, Biostatistics & Occupational Health and of Pediatrics, McGill University Faculty of Medicine, Montreal, Quebec, H3G 1Y6, Canada.
Int Urogynecol J. 2020 Sep;31(9):1829-1837. doi: 10.1007/s00192-019-04132-3. Epub 2019 Nov 28.
The objective was to identify the prevalence and risk factors for urinary incontinence (UI) in healthy midlife Singaporean women.
Healthy women, aged 45-69 years, were assessed for UI and sociodemographic characteristics, including ethnicity, menopausal status, parity, and body mass index (BMI). UI subtypes corresponding to stress (SUI) alone, urge (UUI) alone, mixed (MUI), and leakage (drops only) incontinence were classified using the Urinary Distress Inventory 6 (UDI-6). Risk factors were examined using Chi-squared tests, followed by sequential multivariate logistic regression to estimate adjusted odds ratios (aOR and 95% confidence intervals).
A total of 1,119 women (mean age 56.2 ± 5.2) completed the UDI-6. 52.3% reported any UI; MUI and SUI were the most common, each affecting 20% of women. Post-menopausal women had a lower risk (aOR 0.5 [0.3-0.9]) of SUI, but a higher risk (aOR 4.4 [1.0-19.9]) of UUI compared with premenopausal women. Higher education was negatively associated (aOR 0.3 [0.2-0.7]) with UUI, but positively associated with MUI (aOR 2.3 [1.3-4.0]). Parity (1-2 children) increased the risk of SUI (aOR 1.8 [1.0-3.1]), but reduced the risk of UUI (aOR 0.4 [0.2-0.9]). Obesity was associated with increased risk for MUI (aOR 2.2 [1.4-3.4]) and leakage (aOR 2.0 [1.0-4.1]). Malays and Indians had a higher risk of MUI, having (aOR 2.1 (1.2-3.7) and 1.7 (1.1-2.7) respectively compared with Chinese, a difference mediated by higher BMI.
Urinary incontinence is a major morbidity prevalent in healthy midlife Asian women. Post-menopausal status, education level, parity, BMI (and its link with ethnicity) are independent risk factors in this population, and should be incorporated into counseling and targeted interventions.
本研究旨在确定新加坡中年健康女性中尿失禁(UI)的患病率和危险因素。
对 45-69 岁的健康女性进行 UI 评估和社会人口学特征评估,包括种族、绝经状态、产次和体重指数(BMI)。使用尿窘迫量表 6(UDI-6)对相应的压力性尿失禁(SUI)、急迫性尿失禁(UUI)、混合性尿失禁(MUI)和漏尿(仅滴尿)失禁亚型进行分类。使用卡方检验检查危险因素,然后进行逐步多变量逻辑回归以估计调整后的优势比(aOR 和 95%置信区间)。
共有 1119 名女性(平均年龄 56.2±5.2)完成了 UDI-6。52.3%的女性报告有任何 UI;MUI 和 SUI 最常见,各影响 20%的女性。与绝经前女性相比,绝经后女性发生 SUI 的风险较低(aOR 0.5[0.3-0.9]),但发生 UUI 的风险较高(aOR 4.4[1.0-19.9])。较高的教育程度与 UUI 呈负相关(aOR 0.3[0.2-0.7]),但与 MUI 呈正相关(aOR 2.3[1.3-4.0])。产次(1-2 个孩子)增加 SUI 的风险(aOR 1.8[1.0-3.1]),但降低 UUI 的风险(aOR 0.4[0.2-0.9])。肥胖与 MUI(aOR 2.2[1.4-3.4])和漏尿(aOR 2.0[1.0-4.1])的风险增加有关。马来人和印度人发生 MUI 的风险较高,与中国人相比,分别为(aOR 2.1[1.2-3.7]和 1.7[1.1-2.7]),这一差异与较高的 BMI 有关。
尿失禁是亚洲中年健康女性的主要发病率。绝经后状态、教育程度、产次、BMI(及其与种族的关联)是该人群的独立危险因素,应纳入咨询和针对性干预。