Department of Obstetrics and Gynecology, National University Hospital, National University of Singapore, Singapore, Singapore.
Biostatistics Unit, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
PLoS One. 2023 Jan 30;18(1):e0281144. doi: 10.1371/journal.pone.0281144. eCollection 2023.
This study aimed to examine sarcopenia prevalence using the Asian Working Group for Sarcopenia 2019 (AWGS) and the Foundation for the National Institutes of Health (FNIH) definitions, and their associations with important health conditions affecting midlife Singaporean women. Muscle mass and function were objectively assessed in 1201 healthy community-dwelling subjects aged 45-69 years under the Integrated Women's Health Program (IWHP). Dual-energy X-ray absorptiometry (DXA), handgrip strength and the Short Physical Performance Battery (SPPB) were measured, and the relationship between sarcopenia with hypertension, type 2 diabetes (T2DM), osteoporosis, depression/anxiety, and urinary incontinence were examined using binary logistic regression models. Sarcopenia prevalence was 18.0% and 7.7% by the AWGS and FNIH criteria respectively. Osteoporosis (aOR: 1.74, 95% CI: 1.02, 2.94) and T2DM (aOR: 1.98, 95% CI: 1.14, 3.42) was positively associated with AWGS- and FNIH-defined sarcopenia respectively, while hypertension was not, after adjustment for age, ethnicity, education levels and menopausal status. A negative percent agreement of 95.6% suggests good agreement between the criteria in the absence of sarcopenia. Even though they represent a single concept, sarcopenia by either criterion differed in their relationships with diabetes and osteoporosis, suggesting the need for further rationalization of diagnostic criteria.
本研究旨在使用亚洲肌肉减少症工作组 2019 年（AWGS）和美国国立卫生研究院基金会（FNIH）的定义来检测肌少症的流行率，并探讨其与影响中年新加坡女性的重要健康状况的关系。在综合妇女健康计划（IWHP）下，对 1201 名年龄在 45-69 岁的健康社区居民进行了肌肉质量和功能的客观评估。使用双能 X 线吸收法（DXA）、握力和简短体能表现电池测试（SPPB）进行测量，并使用二元逻辑回归模型检查肌少症与高血压、2 型糖尿病（T2DM）、骨质疏松症、抑郁/焦虑和尿失禁之间的关系。根据 AWGS 和 FNIH 标准，肌少症的患病率分别为 18.0%和 7.7%。在调整年龄、种族、教育水平和绝经状态后，与 FNIH 定义的肌少症相比，骨质疏松症（优势比：1.74，95%置信区间：1.02，2.94）和 T2DM（优势比：1.98，95%置信区间：1.14，3.42）与 AWGS 定义的肌少症呈正相关，而高血压则不然。在不存在肌少症的情况下，两种标准之间的阴性一致率为 95.6%，提示两者具有良好的一致性。尽管它们代表了一个单一的概念，但根据任何一个标准定义的肌少症与糖尿病和骨质疏松症的关系不同，这表明需要进一步合理化诊断标准。
