Laboratory of Phototherapy and Innovative Technologies in Health (LaPIT), Nove de Julho University (UNINOVE), Sao Paulo, Brazil.
Postgraduate Program in Rehabilitation Sciences, Nove de Julho University (UNINOVE), Sao Paulo, Brazil.
Lasers Med Sci. 2020 Aug;35(6):1253-1262. doi: 10.1007/s10103-019-02898-y. Epub 2019 Nov 28.
Identify the optimal energy delivered with a single application of the combination of photobiomodulation therapy (PBMT) combining different light sources (low-level laser therapy-LLLT and light emitting diode therapy-LEDT) and static magnetic field (sMF) in order to determine the acute effects on functional mobility of stroke survivors. Was conducted a randomized, placebo-controlled, crossover, triple-blind, clinical trial (RCT). Twelve patients were recruited, however ten concluded the study, they were randomly treated with four PBMT/sMF energies (sham-0 J, 10 J, 30 J, and 50 J per site irradiated), with 1-week interval washout between treatments. PBMT/sMF were administered after the pre-intervention (baseline) evaluation and the total energy delivered per site at each treatment was determined based on the results of the randomization procedure. PBMT/sMF were administered in direct contact with the skin and applied with slight pressure to nine sites on the knee extensors, six sites on the knee flexors, and two sites on the plantar flexors' muscles in both lower limbs (bilaterally). The primary outcome measure was the 6-min walk test (6MWT) and the secondary outcome was the Timed Up and Go (TUG) test. Significant improvements were found in the 6MWT test using a total energy of 30 J per site compared with sham (0 J) (p < 0.05) and compared with the baseline evaluation (p < 0.01). And in the TUG test significant improvements were also found using a total energy per site of 30 J per site compared to sham (0 J) and baseline (p < 0.05). PBMT with different light sources (laser and LEDs) and wavelengths in combination with sMF with a total energy per site of 30 J has positive acute effects on functional mobility in stroke survivors.
确定单次应用组合光生物调节疗法(PBMT)结合不同光源(低水平激光疗法-LLLT 和发光二极管疗法-LEDT)和静磁场(sMF)的最佳能量,以确定对中风幸存者功能移动性的急性影响。进行了一项随机、安慰剂对照、交叉、三盲、临床试验(RCT)。共招募了 12 名患者,但有 10 名患者完成了研究,他们随机接受了四种 PBMT/sMF 能量(假照射-0 J、10 J、30 J 和 50 J/照射部位)治疗,治疗之间有 1 周洗脱期。PBMT/sMF 在干预前(基线)评估后进行,根据随机分组程序的结果确定每个治疗部位的总能量。PBMT/sMF 在直接接触皮肤的情况下应用,对下肢(双侧)膝关节伸展肌的 9 个部位、膝关节弯曲肌的 6 个部位和足底屈肌的 2 个部位施加轻微压力。主要结局测量是 6 分钟步行测试(6MWT),次要结局是计时起立行走测试(TUG)。与假照射(0 J)相比,与基线评估相比,使用每个部位 30 J 的总能量,6MWT 测试发现显著改善(p < 0.05)。与假照射(0 J)和基线相比,使用每个部位 30 J 的总能量,TUG 测试也发现显著改善(p < 0.05)。使用不同光源(激光和 LED)和波长的 PBMT 结合每个部位 30 J 的总能量对中风幸存者的功能移动性具有积极的急性影响。
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