Burn Institute, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Republic of Korea.
Department of Physical Medicine and Rehabilitation, Burn center, Hangang Sacred Heart Hospital, College of Medicine, Hallym University, Republic of Korea.
Biomater Sci. 2020 Feb 7;8(3):823-829. doi: 10.1039/c9bm01209e. Epub 2019 Nov 29.
Human skin incurs damage in various ways; a few of the recognizable factors are electric burns, chemical burns, scalding burns, surgery, and physical injuries, such as automobile accidents. If skin damage is extensive and severe enough [second degree and total body surface area (TBSA) involvement of >20%], the skin will lose the ability to regenerate itself. Burn wounds are treated in various ways. For full-thickness skin defects, the mainstay of treatment is an autologous split-thickness skin graft. However, there are some limitations due to scars, poor elasticity, and limitations in the joint movements due to contractures. Recently, artificial dermis has been widely used to minimize contractures. The use of dermal replacements for the treatment of burns brings new hope in maintaining the characteristics of the normal dermis. Herein, Insuregraf® was used for skin regeneration in patients who had burn injury from flames, electricity, heat, or steam. The mean take-rate values at 7 and 14 days after operation were 94.55 ± 3.02% and 97.40 ± 2.57%, respectively. Furthermore, areas covered by Insuregraf® showed higher mean values of trans-epidermal water loss (24.6 ± 3.9 g h m), gross elasticity (Ua/Uf = 0.76 ± 0.24), and biological elasticity (Ur/Uf = 0.55 ± 0.1). These values were much better than those of the control where Insuregraf® was not used (p = 0.030, p = 0.040, and p = 0.013, respectively). Furthermore, the biomechanical scar properties of Insuregraf® and Matriderm were very similar. Hence, we suggest that Insuregraf® can be used in the medical field.
人体皮肤会受到各种方式的损伤；一些可识别的因素包括电烧伤、化学烧伤、烫伤烧伤、手术以及物理损伤，如车祸。如果皮肤损伤广泛且严重[二度和总面积（TBSA）> 20%]，皮肤将丧失自我再生的能力。烧伤伤口有多种治疗方法。对于全层皮肤缺损，主要的治疗方法是自体断层皮片移植。然而，由于疤痕、弹性差以及挛缩导致关节运动受限，存在一些局限性。最近，人工真皮已广泛用于最大限度地减少挛缩。真皮替代品用于治疗烧伤，可以为维持正常真皮的特性带来新的希望。在这里，Insuregraf®用于治疗火焰、电击、热或蒸汽引起的烧伤患者的皮肤再生。术后 7 天和 14 天的平均成活率分别为 94.55±3.02%和 97.40±2.57%。此外，Insuregraf®覆盖的区域显示出更高的经皮水分丢失平均值（24.6±3.9 g h m）、总弹性（Ua/Uf=0.76±0.24）和生物弹性（Ur/Uf=0.55±0.1）。这些值明显优于未使用 Insuregraf®的对照组（p=0.030、p=0.040 和 p=0.013）。此外，Insuregraf®和 Matriderm 的生物力学疤痕特性非常相似。因此，我们建议 Insuregraf®可用于医学领域。
