Ohnishi A, Yamamoto T, Murai Y, Hayashida Y, Hori H, Tanaka I
Department of Neurology, University of Occupational and Environmental Health, Kitakyushu, Japan.
Arch Environ Health. 1988 Sep-Oct;43(5):353-6. doi: 10.1080/00039896.1988.9934948.
In Wistar rats subjected daily to a 6-hr exposure of propylene oxide (PO) at a concentration of 1,500 ppm (5 times a wk for 7 wk), ataxia developed in the hindlegs. Myelinated fibers in hindleg nerves and in the fasciculus gracilis showed axonal degeneration, sparing the nerve cell body of the first sacral dorsal root ganglion and myelinated fibers of the first sacral dorsal and ventral roots. These pathologic findings are compatible with central-peripheral distal axonopathy. This is apparently the first animal model of PO neuropathy to be verified histologically.
在每日暴露于浓度为1500 ppm的环氧丙烷（PO）6小时的Wistar大鼠中（每周5次，共7周），后肢出现共济失调。后肢神经和薄束中的有髓纤维显示轴突变性，第一骶背根神经节的神经细胞体以及第一骶背根和腹根的有髓纤维未受影响。这些病理发现与中枢-外周远端轴索性神经病相符。这显然是首个经组织学证实的PO神经病动物模型。
