牙缺失与颅面形态模式有关吗？系统评价和荟萃分析。

Is dental agenesis associated with craniofacial morphology pattern? A systematic review and meta-analysis.

机构信息

Postgraduate Program in Dentistry, School of Dentistry, Fluminense Federal University, Niterói, RJ, Brazil.

Postgraduate Program in Dentistry, School of Dentistry, Fluminense Federal University, Health Institute of Nova Friburgo, RJ, Brazil.

出版信息

Eur J Orthod. 2020 Nov 3;42(5):534-543. doi: 10.1093/ejo/cjz087.

DOI:10.1093/ejo/cjz087

PMID:31783403

Abstract

BACKGROUND/OBJECTIVE: Craniofacial discrepancies have been associated with congenital dental anomalies. The aim of this study was to determine if there is any scientific evidence in the literature regarding the association between dental agenesis and craniofacial morphology.

MATERIALS AND METHODS

A systematic review and meta-analysis following the PRISMA Statement were conducted and registered in PROSPERO database. A broad search was conducted on databases (PubMed, Virtual Health Library, Web of Science, and Scopus) and grey literature. Articles that were selected based on predetermined eligibility criteria were assessed for quality and risk of bias according to the guidelines described by Folkes and Fulton. Those articles with similarities were submitted to meta-analysis using the RevMan 5.3 program. The certainty of the evidence was tested using the GRADE (Grading of Recommendations, Assessment, Development and Evaluation).

RESULTS

An electronic search of 975 articles resulted in 12 articles. These and four articles identified through manual search were eligible to be assessed for methodological quality and the risk of bias. Eleven articles presented moderate to high methodological quality. The included articles observed a reduced mandibular plane, a smaller maxilla and more differences with the increase in the severity of dental agenesis. Seven articles were included in the meta-analyses. Dental agenesis presented smaller SNA angle (P < 0.0001/CI -1.74 [-2.55, -0.92]) with moderate certainty of the evidence; and smaller ANB angle (P = 0.01/CI -0.80 [-1.44, -0.17]), with low certainty of the evidence.

CONCLUSIONS

This systematic review and meta-analysis demonstrated that dental agenesis may be associated with specific craniofacial morphology. Further studies are necessary due to the variation of the certainty of the evidence.

CONFLICT OF INTEREST

none declared.

REGISTRATION

PROSPERO (CRD42017055882).

摘要

背景/目的：颅面畸形与先天性牙齿异常有关。本研究旨在确定文献中是否有关于牙缺失与颅面形态之间关联的科学证据。

材料和方法

根据 PRISMA 声明进行了系统评价和荟萃分析，并在 PROSPERO 数据库中进行了注册。在数据库（PubMed、虚拟健康图书馆、Web of Science 和 Scopus）和灰色文献中进行了广泛搜索。根据 Folkes 和 Fulton 所述指南，基于预定的入选标准选择文章，并根据质量和偏倚风险评估标准对其进行评估。那些具有相似性的文章使用 RevMan 5.3 程序进行荟萃分析。使用 GRADE（推荐、评估、制定和评价）测试证据的确定性。

结果

对 975 篇文章进行电子检索，得到 12 篇文章。这些文章以及通过手动搜索确定的 4 篇文章符合评估方法学质量和偏倚风险的条件。11 篇文章具有较高的方法学质量。纳入的文章观察到下颌平面减小，上颌较小，并且随着牙缺失严重程度的增加，差异更大。7 篇文章纳入荟萃分析。牙缺失表现出较小的 SNA 角（P<0.0001/CI-1.74 [-2.55，-0.92]），具有中等确定性的证据；较小的 ANB 角（P=0.01/CI-0.80 [-1.44，-0.17]），具有低确定性的证据。