Centre of Biosciences, Slovak Academy of Sciences, Institute of Animal Biochemistry and Genetics, Dúbravská cesta 9, Bratislava, Slovakia.
Yeast. 2020 Jan;37(1):73-92. doi: 10.1002/yea.3451. Epub 2019 Dec 22.
The fission yeast Schizosaccharomyces pombe is an important model organism for the study of fundamental questions in eukaryotic cell and molecular biology. A plethora of cellular processes are membrane associated and/or dependent on the proper functioning of cellular membranes. Phospholipids are not only the basic building blocks of cellular membranes; they also serve as precursors to numerous signaling molecules. In this review, we describe the biosynthetic pathways leading to major S. pombe phospholipids, how these pathways are regulated, and what is known about degradation and turnover of fission yeast phospholipids. This review also addresses the synthesis, regulation and the role of water-soluble phospholipid precursors. The last chapter of the review is devoted to the use of S. pombe for the biotechnological production of value-added lipid molecules.
裂殖酵母 Schizosaccharomyces pombe 是研究真核细胞和分子生物学基本问题的重要模式生物。大量的细胞过程与膜相关，或者依赖于细胞膜的正常功能。磷脂不仅是细胞膜的基本组成部分；它们还是许多信号分子的前体。在这篇综述中，我们描述了导致主要的 S. pombe 磷脂的生物合成途径，这些途径是如何被调节的，以及关于裂殖酵母磷脂的降解和周转的了解。这篇综述还讨论了水溶性磷脂前体的合成、调节和作用。综述的最后一章专门介绍了利用 S. pombe 生物技术生产高附加值脂质分子。
